Gene expression
Recent articles
Cell ‘antennae’ link autism, congenital heart disease
Variants in genes tied to both conditions derail the formation of cilia, the tiny hair-like structure found on almost every cell in the body, a new study finds.
Cell ‘antennae’ link autism, congenital heart disease
Variants in genes tied to both conditions derail the formation of cilia, the tiny hair-like structure found on almost every cell in the body, a new study finds.
Four autism subtypes map onto distinct genes, traits
An analysis of more than 5,000 autistic children and their siblings underscores the idea that autism can be understood as multiple conditions with distinct trajectories.
Four autism subtypes map onto distinct genes, traits
An analysis of more than 5,000 autistic children and their siblings underscores the idea that autism can be understood as multiple conditions with distinct trajectories.
Memory study sparks debate over statistical methods
Critics of a 2024 Nature paper suggest the authors failed to address the risk of false-positive findings. The authors argue more rigorous methods can result in missed leads.
Memory study sparks debate over statistical methods
Critics of a 2024 Nature paper suggest the authors failed to address the risk of false-positive findings. The authors argue more rigorous methods can result in missed leads.
Learning in living mice defies classic synaptic plasticity rule
Donald Hebb’s theory—memorably summarized as “cells that fire together, wire together”—does not explain the shifting hippocampal connections in mice learning to navigate a virtual environment, according to a new study.
Learning in living mice defies classic synaptic plasticity rule
Donald Hebb’s theory—memorably summarized as “cells that fire together, wire together”—does not explain the shifting hippocampal connections in mice learning to navigate a virtual environment, according to a new study.
Unexpected astrocyte gene flips image of brain’s ‘stalwart sentinels’
The genetic marker upends the accepted orientation of non-star-like astrocytes in the glia limitans superficialis.
Unexpected astrocyte gene flips image of brain’s ‘stalwart sentinels’
The genetic marker upends the accepted orientation of non-star-like astrocytes in the glia limitans superficialis.
New tool may help untangle downstream effects of autism-linked genes
The statistical approach helps scientists better control for both measured and unmeasured confounders in gene-expression data, revealing causal relationships between autism-linked genetic variants and downstream cellular effects, such as impaired neuron development.
New tool may help untangle downstream effects of autism-linked genes
The statistical approach helps scientists better control for both measured and unmeasured confounders in gene-expression data, revealing causal relationships between autism-linked genetic variants and downstream cellular effects, such as impaired neuron development.
Molecular changes after MECP2 loss may drive Rett syndrome traits
Knocking out the gene in adult mice triggered up- and down-regulated expression of myriad genes weeks before there were changes in neuronal function.
Molecular changes after MECP2 loss may drive Rett syndrome traits
Knocking out the gene in adult mice triggered up- and down-regulated expression of myriad genes weeks before there were changes in neuronal function.
Sequencing study spotlights tight web of genes tied to autism
The findings, shared in a preprint, help to illuminate how a large and heterogeneous group of genes could be involved in autism.
Sequencing study spotlights tight web of genes tied to autism
The findings, shared in a preprint, help to illuminate how a large and heterogeneous group of genes could be involved in autism.
Cell ‘fingerprints’ identify distinct cortical networks
These networks align with different assemblages of cells, a finding that could reveal how cellular diversity influences brain function, according to a new study.
Cell ‘fingerprints’ identify distinct cortical networks
These networks align with different assemblages of cells, a finding that could reveal how cellular diversity influences brain function, according to a new study.
Protein aggregates gum up ‘master regulator’ of autism-linked genes
The regulator, CPEB4, typically controls protein production for hundreds of autism-linked genes, but an alternative version of it found in autistic people forms irreversible clumps and malfunctions.
Protein aggregates gum up ‘master regulator’ of autism-linked genes
The regulator, CPEB4, typically controls protein production for hundreds of autism-linked genes, but an alternative version of it found in autistic people forms irreversible clumps and malfunctions.
Explore more from The Transmitter
This paper changed my life: Abigail Person on birdsong, feed-forward circuits and convergent computations
By isolating specific neuron types involved in zebra finch birdsong, this 2002 Nature paper from Michael Fee and colleagues revealed elegant neural mechanisms controlling the timing of natural learned behavior.
This paper changed my life: Abigail Person on birdsong, feed-forward circuits and convergent computations
By isolating specific neuron types involved in zebra finch birdsong, this 2002 Nature paper from Michael Fee and colleagues revealed elegant neural mechanisms controlling the timing of natural learned behavior.
Prosocial effects of oxytocin are state dependent; and more
Here is a roundup of autism-related news and research spotted around the web for the week of 11 August.
Prosocial effects of oxytocin are state dependent; and more
Here is a roundup of autism-related news and research spotted around the web for the week of 11 August.
The challenge of defining a neural population
Our current approach is largely arbitrary. We need new methods for grouping cells, ideally by their dynamics.
The challenge of defining a neural population
Our current approach is largely arbitrary. We need new methods for grouping cells, ideally by their dynamics.