Hippocampus

Recent articles

Research image of portions of the adult dentate gyrus.

Machine learning spots neural progenitors in adult human brains

But the finding has not settled the long-standing debate over the existence and extent of neurogenesis during adulthood, says Yale University neuroscientist Juan Arellano.

By Claudia López Lloreda
3 July 2025 | 7 min listen
Research image of excitatory neurons in the mouse hippocampus.

Spatial learning circuitry fluctuates in step with estrous cycle in mice

Cyclic shifts in estradiol levels coincide with changes in dendritic spine density and the activity of place cells in the CA1 region of the hippocampus, a new study shows.

By Sydney Wyatt
25 June 2025 | 6 min listen

Expanded view of hippocampal function comes into focus

After decades of debate, the region’s role is being rewritten. Rather than using sensory input to simply log key points in time and space, the hippocampus may serve to contextualize our experiences and memories—and ultimately make predictions about the future.

By Natalia Mesa
24 June 2025 | 11 min listen
Photograph of a chickadee.

Gazing at a location from afar activates place cells in chickadees

The results help explain how the hippocampus can recall information about a place without an animal physically revisiting it.

By Marta Hill
13 June 2025 | 6 min listen
Illustration of synapse-like threads connecting in various ways.

Learning in living mice defies classic synaptic plasticity rule

Donald Hebb’s theory—memorably summarized as “cells that fire together, wire together”—does not explain the shifting hippocampal connections in mice learning to navigate a virtual environment, according to a new study.

By Sydney Wyatt
28 May 2025 | 6 min listen
Image of brain cell activity in rat brains.

Sleep doesn’t just consolidate memories; it actively shapes them

The rapid eye movement (REM) phase preserves newly acquired memories, but deeper non-REM sleep helps to adapt and update them, according to “heroic” day-long electrode recordings in rats.

By Giorgia Guglielmi
6 May 2025 | 6 min listen
Cognitive neuroscientist Nick Turk-Browne helps an infant into an fMRI machine.

What infant fMRI is revealing about the developing mind

Cognitive neuroscientists have finally clocked how to perform task-based functional MRI experiments in awake babies—long known for their inability to lie still or take direction. Next, they aim to watch cognition take shape and settle a debate about our earliest memories—with one group publishing a big clue today.

By Calli McMurray
20 March 2025 | 12 min read
A mouse sits on a gloved hand.

Molecular changes after MECP2 loss may drive Rett syndrome traits

Knocking out the gene in adult mice triggered up- and down-regulated expression of myriad genes weeks before there were changes in neuronal function.

By Chloe Williams
20 March 2025 | 5 min read
Patient being administered an EEG test.

Single-neuron recordings are helping to unravel complexities of human cognition

As this work begins to bear fruit, researchers “are becoming less afraid to ask very difficult questions that you can uniquely ask in people.”

By Claudia López Lloreda
14 March 2025 | 10 min listen

Alison Preston explains how our brains form mental frameworks for interpreting the world

Preston discusses her research examining differences in how children, teenagers and adults integrate new information into their memories.

By Paul Middlebrooks
12 March 2025 | 90 min listen

Explore more from The Transmitter

Emotion research has a communication conundrum

In 2025, the words we use to describe emotions matter, but their definitions are controversial. Here, I unpack the different positions in this space and the rationales behind them—and I invite 13 experts to chime in.

By Nicole Rust
5 September 2025 | 37 min listen

Autism-linked copy number variants always boost autism likelihood

By contrast, varied doses of the same genes decrease or increase the odds of five other conditions, with distinct biological consequences, two new preprints show.

By Natalia Mesa
4 September 2025 | 7 min listen

Everything everywhere all at once: Decision-making signals engage entire brain

The findings, gleaned from the most comprehensive map yet of brain activity during decision-making in mice, show that the process is even more distributed than previously thought.

By Claudia López Lloreda
3 September 2025 | 5 min read

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