SHANK1

Recent articles

Oil and water with colors behind: blue, green, yellow and red.

How microscopic ‘condensates’ in cells might contribute to autism

A controversial idea about how cells compartmentalize their contents into droplets — like beads of oil in water — could be key to understanding autism, says Julie Forman-Kay.

By Angie Voyles Askham
23 February 2021 | 7 min read
Spectrum from The Transmitter.

The treasures of monkey island

On Cayo Santiago island, scientists track the alliances and power struggles of a colony of feral monkeys — collecting data to generate new insights into the social challenges that people with autism face.

By Brendan Borrell
22 June 2016 | 23 min read
Spectrum from The Transmitter.

Neighboring mutations in gene may spawn separate conditions

Two seemingly similar mutations in the SHANK3 gene have divergent effects on the brain and behavior.

By Jessica Wright
25 January 2016 | 4 min read
Spectrum from The Transmitter.

Rodent learning sheds light on missed social cues in autism

Many people with autism have trouble interpreting and responding to social cues. Studying how rats learn from each other can provide insights into the human social brain, says Amiel Rosenkranz.

By Amiel Rosenkranz
28 July 2015 | 9 min read
Spectrum from The Transmitter.

Family of autism-linked proteins helps neurons communicate

The SHANK family of proteins, some of which are strong autism candidates, work together to facilitate brain signaling, according to unpublished results presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

By Jessica Wright
16 November 2014 | 3 min read
Spectrum from The Transmitter.

SHANK3 mutations turn up in high proportion of autism cases

About 2 percent of people who have both autism and intellectual disability carry harmful mutations in SHANK3, a protein that helps organize the connections between neurons, according to a study published 4 September in PLoS Genetics.

By Jessica Wright
18 September 2014 | 4 min read
Spectrum from The Transmitter.

Drug fixes cellular defects in autism-related disorder

A new stem-cell model of Phelan-McDermid syndrome points to a possible treatment for the rare autism-related disorder, according to a study published in Nature.

By Virginia Hughes
2 December 2013 | 5 min read
Spectrum from The Transmitter.

Where will the focus on SHANK genes lead?

Geneticists react to discoveries and identify next steps for one of autism’s most promising candidate genes.

By Greg Boustead
11 November 2013 | 5 min read
Spectrum from The Transmitter.

SHANK mutations converge at neuronal junctions in autism

SHANK3, one of the strongest candidate genes for autism, has the potential to be a molecular entry point into understanding the synaptic, developmental and circuit origins of the disorder.  

By Meera Modi, Michael Ehlers
5 November 2013 | 6 min read
Spectrum from The Transmitter.

Risk factors

To focus the search for environmental risk factors in autism, we should look for chemicals that influence the molecular pathways associated with candidate risk genes, say Pamela Lein and Marianna Stamou.

By Pamela Lein, Marianna Stamou
26 February 2013 | 3 min read

Explore more from The Transmitter

Research image of EEG scans showing dopamine levels in human brains.

Null and Noteworthy: Learning theory validated 20 years later

The first published paper from the EEGManyLabs replication project nullifies a null result that had complicated a famous reinforcement learning theory.

By Laura Dattaro
30 May 2025 | 4 min read
Gerry Fischbach.

Neuroscientist Gerry Fischbach, in his own words

In 2023, I had the privilege of sitting down with Gerry over the course of several days and listening as he told the story of his life and career—including stints as dean or director of such leading institutions as Columbia University and NINDS—so that we could record it for posterity.

By Ivan Oransky
30 May 2025 | 2 min read
Amina Abubakar, dressed in yellow, stands outside and looks into the camera lens.

Amina Abubakar translates autism research and care for Kenya

First an educator and now an internationally recognized researcher, the Kenyan psychologist is changing autism science and services in sub-Saharan Africa.

By Ruth Kadide Keah
29 May 2025 | 7 min read