DYRK1A

A research image of a mouse hippocampus

Some social issues in DYRK1A model mice stem from faulty inhibitory circuits

Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.

By Giorgia Guglielmi
11 October 2023 | 4 min read
Research image of zebrafish forebrains.

Autism-related genes converge on microglia and dopamine in zebrafish

The findings add to the growing evidence that genes with disparate functions can play similar roles in brain development.

By Peter Hess
12 May 2023 | 4 min read
Lab images of cilia.
Spectrum Microphone

Autism and the cell’s antennae

Many autism-linked genes are somehow tied to cilia, the tiny hair-like sensors that stud a cell’s surface. But the question remains whether, and how, cilia differences contribute to the condition.

By Giorgia Guglielmi
4 January 2023 | 6 min read

Screening zebrafish autism models: A quick take at SfN with Ellen Hoffman

Zebrafish with mutations in 10 different autism-linked genes show a range of unique and shared phenotypes.

By Spectrum
16 November 2022 | 2 min watch
Illustration shows yellow landscape with blue sections and a lot of trains on paths with kids on the trains, going different directions.
Spectrum Microphone

Mapping the futures of autistic children

Researchers can roughly project what autistic children's lives will look like years down the road. But how good is their crystal ball — and what are its benefits?

By Elizabeth Svoboda
14 July 2021 | 18 min read
Two views of mouse brain slices colorized in green and red.

Jump-starting growth signaling reverses microcephaly in autism mouse model

A genetic therapy and an existing drug both restore typical brain size in mice missing DYRK1A, a top autism candidate gene, in the cerebral cortex, a new study shows. The animals typically have smaller brains than controls.

By Peter Hess
29 April 2021 | 4 min read
Oil and water with colors behind: blue, green, yellow and red.

How microscopic ‘condensates’ in cells might contribute to autism

A controversial idea about how cells compartmentalize their contents into droplets — like beads of oil in water — could be key to understanding autism, says Julie Forman-Kay.

By Angie Voyles Askham
23 February 2021 | 7 min read
Spectrum Microphone

Mutations in frogs point to autism genes’ shared role in neurogenesis

Mutations in any of 10 autism-linked genes in frogs lead to the same overabundance of brain cells that develop into neurons; the sex hormone estrogen lowers this excess.

By Laura Dattaro
10 February 2021 | 6 min read
children playing at a genetic family group meeting

How families are driving the study of autism genes

Parents of children with rare autism-linked mutations are banding together for support and to join forces with scientists, accelerating the pace of research.

By Jessica Wright
10 April 2019 | 14 min read
Grid of 8 portraits of children with characteristic facial features

Small head, speech delay characterize mutations in autism gene

Children with mutations in a gene called DYRK1A, a leading autism candidate, have a distinct set of features, including intellectual disability, speech delay, motor problems and a small head.

By Jessica Wright
16 October 2017 | 4 min read

Explore more from The Transmitter

Research illustration groups genes by their effects on brain cell types.

Giant analysis reveals how autism-linked genes affect brain cell types

Genes that predispose people to autism account for a large portion of the neuronal and glial cell changes seen in those with the condition.

By Charles Q. Choi
20 June 2024 | 5 min read

Widely used calcium imaging protocol can lead to spurious results, new paper cautions

The technique, which measures calcium currents as a proxy for neuronal firing, sometimes reports unusual and potentially misleading waves of activity in the hippocampus.

By Angie Voyles Askham
19 June 2024 | 0 min watch
Research image of white-matter density in brains of people with deletions or duplications in the 16p11.2 chromosomal region.

Double-empathy problem; dup15q syndrome; myelin loss in aging autistic adults

Here is a roundup of autism-related news and research spotted around the web for the week of 17 June.

By Jill Adams
18 June 2024 | 2 min read