FMRP

Autism research hits the road

Some scientists are thinking creatively about how to collect data in flexible environments and meet communities where they’re at.

By Giorgia Guglielmi
8 December 2023 | 0 min watch
Research image of neurons in mice.

Skewed signaling in striatum may spawn repetitive behaviors

Synaptic changes in the brain region could drive a core trait of fragile X syndrome, a new mouse study suggests.

By Holly Barker
6 September 2023 | 3 min read
Research images of protein synthesis in mice.

Neuronal deafness to stress may add to protein surplus in fragile X

A protective pathway that pauses protein synthesis is muted in a mouse model of fragile X syndrome, according to a new study.

By Holly Barker
29 August 2023 | 3 min listen
Illustration of a fragile X syndrome chromosome.
Genes Microphone

New gene-editing method flags fragile X mutation for repair

The approach prompts cultured cells to correct the genetic mutation in fragile X syndrome using their own DNA repair system, but it still needs to be tested further.

By Angie Voyles Askham
5 July 2023 | 5 min listen
an image of a neuron
Spectrum Microphone

Neurons struggle to spike without fragile X gene

FMR1 loss impairs sodium channels, hindering mouse neurons from generating the electrical signals needed to transmit information.

By Laura Dattaro
17 February 2023 | 3 min read
Research image showing neuronal activity in mice exposed to high-frequency sounds.

Missing mechanism helps solve fragile X protein mystery

Cells from people with fragile X syndrome overproduce — but don’t accumulate — proteins. New work suggests that excessive protein breakdown may account for this discrepancy, and explain some of the syndrome’s traits.

By Giorgia Guglielmi
24 January 2023 | 4 min read
Brain slice of a mouse brain showing cells carrying the fragile X mutation.
Spectrum Microphone

Fragile X neurons develop atypically in chimeric mice

After a brain transplant of reprogrammed human cells, the animals can for the first time recapitulate some neuronal changes seen in people with fragile X syndrome.

By Emma Yasinski
29 September 2022 | 4 min read
Illustration of a binocular microscope with an X Chromosome in one eyepiece and cancer cells in the other.
Spectrum Microphone

The cloudy connection between fragile X and cancer

People with the autism-linked syndrome lack a protein implicated in several cancers, but it’s unclear whether — or how — they are protected from malignancies.

By Giorgia Guglielmi
28 September 2022 | 8 min read
A brown lab mouse perches on a researcher's hand.

Largest-yet fragile X mutation in mice confirms model’s shortcomings

A 341-repeat mutation from a person with fragile X does not lead to the syndrome’s traits or function the same way in mice, highlighting a need for different animal models.

By Peter Hess
14 September 2022 | 3 min read
Spectrum Microphone

Plethora of protein-making machines in neurons may underlie fragile X

An overabundance of ribosomes drives an imbalance of proteins produced from long and short genetic transcripts in a mouse model of fragile X syndrome.

By Chloe Williams
21 July 2022 | 6 min read

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Overgrown organoids could point to mechanisms underlying profound autism.

By Holly Barker
18 July 2024 | 5 min read

Persistent protein pairing enables memories to last

The complex of two memory proteins, rather than the individual molecules acting independently, underlie month-long memories in mice, a new study suggests.

By Elissa Welle
17 July 2024 | 5 min read
A digitally distorted image of a file folder against a blue gradient background.

Data access changes to UK Biobank stir unease in neuroscientists

“I feel a little bit in limbo,” says neuroscientist Stephanie Noble, who has paused a study using Biobank data after the repository shifted from a data download to a cloud-only access model.

By Calli McMurray
16 July 2024 | 7 min read