The BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed) from the National Institutes of Health (NIH) supports projects to develop theories, models and methods (TMM) as tools that will advance a quantitative and predictive understanding of brain function across multiple scales, including behavior. Priority is given to projects that develop novel capabilities for analyzing, integrating, and interpreting the large-scale, complex data emerging from the Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative and related efforts, which includes cell-type specific physiological, anatomical, connectivity, and behavioral data. Proposed experimental work must be limited to model parameter estimation and/or testing the validity of the tools being delivered. Applications are open to research institutions, small businesses, and other for-profit organisations in the USA. Applications are also open to researchers at institutions worldwide, including foreign components of US institutions. The grant provides funding for up to 3 years. Application budgets are not limited, but are expected to range between $150,000 USD to $350,000 USD, direct costs per year.
Funding opportunity number: RFA-DA-27-004
The next applications close on October 6, 2026.