The Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required) funding call from the National Institute of Mental Health (NIMH) supports pilot research developing and testing innovative psychosocial intervention approaches in which the target and/or intervention strategy is novel. Consistent with NIMH’s experimental therapeutics approach, this NOFO is intended to speed the translation of emergent research on mechanisms and processes underlying mental disorders into promising novel psychosocial preventative or therapeutic interventions. Targets may include, but are not limited to, potentially modifiable behavioral, cognitive, affective, and/or interpersonal factors or processes, neural circuits or neural activity subserving specific behaviors or cognitive processes, and/or other neurobiological mechanisms. The R33 is intended to support the replication of target engagement and to test whether engaging the intervention target/mechanism mediates changes in clinical outcomes.
Applications are open to researchers at research institutions in the USA and worldwide, including small businesses and other for-profit organizations.
The grant provides funding for 3 years (plus indirect costs).
Funding opportunity number: PAR-25-181
Assessment closing dates are:
- June 15, 2026
- October 15, 2026
- February 17, 2027
- June 15, 2027
- October 15, 2027