The Effectiveness Trials to Test Mental Health System Interventions (R61/R33 Clinical Trial Required) from the National Institute of Mental Health (NIMH) supports milestone-driven feasibility and infrastructure development (R61) research followed by well-powered clinical trials (R33) to test the effectiveness of system interventions or strategies that improve the organization, delivery, coordination, and outcomes of mental health care for priority populations. System interventions – which may span, for example, structural, policy, and organizational domains – attend to issues about the access, equity, engagement/utilization, value (cost/financing), management, or quality and safety of mental health services, with the goal of improved care processes and clinical, functional, or population level outcomes. Accordingly, the focus of system interventions may include multiple factors/levels related to care delivered within or across a variety of care settings, such as health systems and organizations, mental health and community clinics, schools, and social welfare or justice systems. Projects may test the impact of policies and practices, interventions to facilitate care transitions and continuity across settings, and interventions to improve linkages/coordination across systems. Applications are open to researchers at research institutions in the USA and worldwide, including small businesses and other for-profit organizations.
The grant provides funding for 5 years (plus indirect costs).
Funding opportunity number: PAR-25-285
Applications are due on June 15, 2026.