The Mood and Psychosis Symptoms during the Menopause Transition (R21 Clinical Trial Optional) funding call from the National Institute of Mental Health (NIMH) supports mechanistic and translational research on the onset and worsening of mood and psychotic disorders during the menopausal transition (or perimenopause). In particular, NIMH seeks research that will advance understanding of the underlying neurobiological and behavioral mechanisms of mood disruption, emotion dysregulation, and psychosis during the menopausal transition and that will identify novel targets for future mental health interventions or prevention efforts. Investigators proposing high risk/high reward projects, projects that lack preliminary data, or studies that utilize existing data may wish to apply using the R21 mechanism.
Applications are open to researchers at research institutions in the USA and worldwide.
The grant provides 275,000 USD for 2 years (plus indirect costs).
Funding opportunity number: PAR-25-282
Applications are due: June 16, 2026.