Interneurons

Recent articles

Research image of two mouse brain slices.

Split gene therapy delivers promise in mice modeling Dravet syndrome

The new approach overcomes viral packaging limitations by delivering SCN1A piecemeal and stitching it together in target cells.

By Holly Barker
10 April 2025 | 5 min read
Detailed image of neurons in the mouse visual cortex.

Inhibitory cells work in concert to orchestrate neuronal activity in mouse brain

A cubic millimeter of brain tissue, meticulously sectioned, stained and scrutinized over the past seven years, reveals in stunning detail the role of inhibitory interneurons in brain structure and function.

By Katie Moisse
9 April 2025 | 6 min listen
Illustration of ketamine blocking open ion channels in active NMDA receptors, quieting the cells and disrupting downstream signaling involved in depression.

Ketamine targets lateral habenula, setting off cascade of antidepressant effects

The drug’s affinity for overactive cells in the “anti-reward” region may help explain its rapid and long-lasting results.

By Olivia Gieger
4 September 2024 | 6 min read
Research image of different interneuron subtypes responding to the absence of pyramidal neurons in the mouse cortex.

As circuits wire up, interneurons take cues from surrounding cells

The inhibitory cells’ development, diversity and abundance in the cortex is directed in part by pyramidal cells, a new preprint suggests.

By Olivia Gieger
14 August 2024 | 5 min read
Research image of excitatory synapses in the prefrontal cortex.

Synaptic anomalies in autistic people support imbalance hypothesis

Increased excitatory and decreased inhibitory synapses in the prefrontal cortex of autistic people suggest broader impacts on brain function and connectivity.

By Giorgia Guglielmi
27 June 2024 | 4 min read
Illustration of two neurons with a shared origin point.

Cortical interneurons derive differently in human brains

Excitatory neurons and some inhibitory neurons in the adult human cortex share parents, challenging the longstanding idea that the two cell types have different origins.

By Elissa Welle
20 December 2023 | 6 min read
Research image of various types of cells.

Vast diversity of human brain cell types revealed in trove of new datasets

The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.

By Angie Voyles Askham
12 October 2023 | 7 min listen
Photograph of a gloved hand pointing to a computer screen that is displaying an image of a mouse brain.

Uncertainty and excitement surround one company’s cell therapy for epilepsy

After 10 years of work, Neurona may have the data to quiet its skeptics. But its ongoing clinical trial will be the ultimate test.

By Angie Voyles Askham
5 October 2023 | 20 min listen
A brown mouse looks away from a white mouse in a cage to its left.

‘VIP’ interneurons may drive autism traits in Dravet syndrome

The inhibitory cells misfire and contribute to social difficulties in mice that model the syndrome.

By Lauren Schenkman
19 July 2023 | 6 min read
Research image showing the impact of a gene mutation on a synapse.

Tweaks to autism-linked pathway tilt circuits’ signaling balance

Altered expression of TSC2 and the mTOR pathway reshape the formation of certain synapses between inhibitory and excitatory neurons in mice.

By Angie Voyles Askham
31 January 2023 | 4 min read

Explore more from The Transmitter

Photograph of a chickadee.

Gazing at a location from afar activates place cells in chickadees

The results help explain how the hippocampus can recall information about a place without an animal physically revisiting it.

By Marta Hill
13 June 2025 | 6 min read
An opaque cube is repeated multiple times to create the appearance of overlapping cubes.

Sounding the alarm on pseudoreplication: Q&A with Constantinos Eleftheriou and Peter Kind

Most studies of neurological disorders in mice erroneously treat multiple samples from a single animal as independent replicates, according to a new analysis. But scientists and journals can take steps to curb this practice.

By Lauren Schenkman
12 June 2025 | 6 min read
Crumpled pieces of paper form an X.

Psychedelics meta-analysis retracted after authors request ‘significant changes’

While working on a similar analysis last year, an independent researcher spotted inconsistencies in the now-retracted paper.

By Marta Hill
11 June 2025 | 2 min read