Mouse models
Recent articles
Protein tug-of-war controls pace of synaptic development, sets human brains apart
Human-specific duplicates of SRGAP2 prolong cortical development by manipulating SYNGAP, an autism-linked protein that slows synaptic growth.
Protein tug-of-war controls pace of synaptic development, sets human brains apart
Human-specific duplicates of SRGAP2 prolong cortical development by manipulating SYNGAP, an autism-linked protein that slows synaptic growth.
Boosting SCN2A expression reduces seizures in mice
A modified form of CRISPR amps up expression of the gene—a strategy that could apply to other gene variations linked to autism.
Boosting SCN2A expression reduces seizures in mice
A modified form of CRISPR amps up expression of the gene—a strategy that could apply to other gene variations linked to autism.
Sensory gatekeeper drives seizures, autism-like behaviors in mouse model
The new work, in mice missing the autism-linked gene CNTNAP2, suggests a mechanism to help explain the overlap between epilepsy and autism.
Sensory gatekeeper drives seizures, autism-like behaviors in mouse model
The new work, in mice missing the autism-linked gene CNTNAP2, suggests a mechanism to help explain the overlap between epilepsy and autism.
Up and out with Peggy Mason
Mason helped define the rodent prosocial behavior field, but now she’s changing course.
Up and out with Peggy Mason
Mason helped define the rodent prosocial behavior field, but now she’s changing course.
This paper changed my life: Victoria Abraira on a tasty link between circuits and behavior
The findings from Charles Zuker’s lab put the taste system on the map, revealing that some fundamental principles of behavior are hardwired.
This paper changed my life: Victoria Abraira on a tasty link between circuits and behavior
The findings from Charles Zuker’s lab put the taste system on the map, revealing that some fundamental principles of behavior are hardwired.
Systems and circuit neuroscience need an evolutionary perspective
To identify fundamental neuroscientific principles that generalize across species, neuroscientists must frame their research through an evolutionary lens.
Systems and circuit neuroscience need an evolutionary perspective
To identify fundamental neuroscientific principles that generalize across species, neuroscientists must frame their research through an evolutionary lens.
The big idea with Diego Bohórquez
His theories around the neuropod have challenged the boundaries of classic ideas regarding gut-brain communication.
The big idea with Diego Bohórquez
His theories around the neuropod have challenged the boundaries of classic ideas regarding gut-brain communication.
Sounding the alarm on pseudoreplication: Q&A with Constantinos Eleftheriou and Peter Kind
Most studies of neurological disorders in mice erroneously treat multiple samples from a single animal as independent replicates, according to a new analysis. But scientists and journals can take steps to curb this practice.
Sounding the alarm on pseudoreplication: Q&A with Constantinos Eleftheriou and Peter Kind
Most studies of neurological disorders in mice erroneously treat multiple samples from a single animal as independent replicates, according to a new analysis. But scientists and journals can take steps to curb this practice.
‘Understudied secret’ in brain dampens nicotine drive in mice
The interpeduncular nucleus produces an aversion to nicotine, even at low doses, and helps moderate how rewarding mice find the drug.
‘Understudied secret’ in brain dampens nicotine drive in mice
The interpeduncular nucleus produces an aversion to nicotine, even at low doses, and helps moderate how rewarding mice find the drug.
Escaping groupthink: What animals’ behavioral quirks reveal about the brain
Neuroscientists have long ignored the variability in animals’ behavioral responses in favor of studying differences across groups. But work on the brain differences that underlie that variability is beginning to pay off.
Escaping groupthink: What animals’ behavioral quirks reveal about the brain
Neuroscientists have long ignored the variability in animals’ behavioral responses in favor of studying differences across groups. But work on the brain differences that underlie that variability is beginning to pay off.
Explore more from The Transmitter
First Pan-African neuroscience journal gets ready to launch
With lower-than-average article processing fees, and issues dedicated to topics important to the continent, the journal hopes to give African neuroscience research much-needed international visibility.
First Pan-African neuroscience journal gets ready to launch
With lower-than-average article processing fees, and issues dedicated to topics important to the continent, the journal hopes to give African neuroscience research much-needed international visibility.
New method identifies two-hit genetic variation in autism; and more
Here is a roundup of autism-related news and research spotted around the web for the week of 27 October.
New method identifies two-hit genetic variation in autism; and more
Here is a roundup of autism-related news and research spotted around the web for the week of 27 October.
The missing half of the neurodynamical systems theory
Bifurcations—an underexplored concept in neuroscience—can help explain how small differences in neural circuits give rise to entirely novel functions.
The missing half of the neurodynamical systems theory
Bifurcations—an underexplored concept in neuroscience—can help explain how small differences in neural circuits give rise to entirely novel functions.