Neurodevelopmental disorders

Recent articles

Two paper arrows intersect to form a double helix.

Genetic background steers PTEN syndrome traits

People with the syndrome, caused by variants in the gene PTEN, often have autism or cancer, or both, but it depends on the genetic diversity encoded in the components of distinct cell signaling pathways, according to a new study.

By Holly Barker
19 June 2025 | 5 min listen
Research image of human cortical neurons xenotransplanted into a mouse brain for months.

In vivo veritas: Xenotransplantation can help us study the development and function of human neurons in a living brain

Transplanted cells offer insight into human-specific properties, such as a lengthy cortical development and sensitivity to neurodevelopmental and neurodegenerative disease.

By Pierre Vanderhaeghen
7 April 2025 | 9 min listen
Research image of frog cells.

Many autism-linked proteins influence hair-like cilia on human brain cells

The finding may help explain autism’s association with multiple co-occurring conditions that involve cilia defects.

By Charles Q. Choi
9 January 2025 | 4 min read
Research image of brain scans.

Impaired molecular ‘chaperone’ accompanies multiple brain changes, conditions

Rare genetic variants in a protein-folding complex contribute to a spectrum of phenotypes that encompass brain malformations, intellectual disability, autism and seizures, according to a new “hallmark” study.

By Holly Barker
12 December 2024 | 5 min read
Illustration of a pen hovering over a gene sequence-like series of colored rectangles.

This paper changed my life: ‘Histone demethylation mediated by the nuclear amine oxidase homolog LSD1,’ from the Shi Lab

This paper defined key rules of epigenomic regulation and shaped how I study chromatin plasticity as a mechanism for experience-dependent changes in the brain.

By Anne E. West
27 November 2024 | 5 min read
Stock photograph of a women and her young child at a clinician’s office.

A genetics-first clinic for catching developmental conditions early: Q&A with Jacob Vorstman

A new clinic is assessing children who have a genetic predisposition for autism and other neurodevelopmental conditions—sometimes before traits appear.

By Lauren Schenkman
15 August 2024 | 7 min read
A hand holds a stack of speech bubbles.

Leveraging the power of community to strengthen clinical trials for rare genetic syndromes

Families can become not only participants but champions of these research efforts.

By Shafali Spurling Jeste
11 July 2024 | 7 min read
Research image of a chimeroid.

Brain ‘chimeroids’ reveal person-to-person differences rooted in genetics

These fusions created from multiple donors’ organoids may help scale up comparative brain research.

By Charles Q. Choi
5 July 2024 | 4 min read
Research image of brain activity

Connectivity takes U-turn in people with rare autism-linked mutations

Patterns of brain connectivity shift during puberty in people with deletion of the 22q11.2 chromosomal region.

By Holly Barker
30 May 2024 | 4 min read
Illustration of a conveyor belt spilling pills over a green cliff face.

Acetaminophen use during pregnancy does not increase child’s chance of having autism, study finds

The link reported in prior studies likely reflects confounding factors, which sibling-matched controls in the new work address.

By Calli McMurray
9 April 2024 | 7 min read

Explore more from The Transmitter

Astrocytes sense neuromodulators to orchestrate neuronal activity and shape behavior

Astrocytes serve as crucial mediators of neuromodulatory processes previously attributed to direct communication between neurons, four new studies show.

By Claudia López Lloreda
27 June 2025 | 9 min listen

Authors correct image errors in Neuron paper that challenged microglia-to-neuron conversion

The issue with the supplementary figures likely does not change the conclusions of the paper, according to an outside expert.

By Shaena Montanari
26 June 2025 | 3 min read

Building a climate neuroscience subfield: Q&A with Angie Michaiel

Michaiel, a program officer at the Kavli Foundation, shares what it took to cultivate research on the relationship between climate change and the nervous system.

By Calli McMurray
26 June 2025 | 5 min read