News / Spectrum

Brain Gene Registry; neurite density; income disparities in autism diagnoses

Here is a roundup of autism-related news and research spotted around the web for the week of 29 April.

By Jill Adams

30 April 2024 | 2 min read

https://doi.org/10.53053/DLHK4539

Cite this article

https://doi.org/10.53053/DLHK4539 Cite this article

The growth factor BMP2 seems to be a regulatory target for maintaining the balance of excitatory and inhibitory neurotransmission in the mouse brain. Spectrum has an explainer about the signaling imbalance theory of autism. Nature

Research image of glutaminergic synapses on parvalbumin interneurons. — Missed connections: Mice missing the BMP2 gene (right panels) form fewer glutaminergic synapses onto parvalbumin interneurons than do controls (left panels).

Altered transcription spurred by a variety of autism-linked genes often converges on a small number of developmental pathways, according to a preprint about cortical organoids derived from human induced pluripotent stem cells. bioRxiv
Gene variants linked to autism are also linked to decreased neurite density in the brain, according to a preprint that used UK BioBank data. medRxiv
Low-income families have a higher prevalence of autism diagnoses than do high-income families, according to an analysis by the U.S. Centers for Disease Control and Prevention. Morbidity and Mortality Weekly Report
The U.K. Metropolitan Police are investigating advertisers hawking false claims about stem cell therapy for autism. BBC
A new resource called the Brain Gene Registry contains genetic and phenotypic data from people with intellectual and developmental disabilities; its goal is to help researchers better characterize the links between genes and conditions such as autism and attention-deficit/hyperactivity disorder. Journal of Neurodevelopmental Disorders
Speech-processing difficulties in autistic children may be related to altered integration of auditory and visual stimuli, according to a preprint. bioRxiv
Alterations in executive function in autistic children appear to contribute to the likelihood of having mental health conditions, such as anxiety, depression or aggression. Autism
Mental health conditions affect sleep quality in children with fragile X syndrome, which, in turn, affects daily functioning at school. Journal of Autism and Developmental Disorders
Different variants of the SCN2A gene, which are linked to autism and epilepsy, confer different effects on sodium channel function, and different clinical profiles. Brain

Sign up for the weekly Spectrum newsletter.

Stay current with the latest advancements in autism research.

tags:

Spectrum, Autism, Science and society, Spotted

Recommended reading

Research image visualizing genetic variation.

Spectrum

Long-read sequencing unearths overlooked autism-linked variants

By Natalia Mesa

18 September 2025 | 6 min read

Research image of different types of microglia in mice.

Spectrum

Autism and anxiety insights; and more

By Jill Adams

16 September 2025 | 2 min read

Research image showing cell activity in a particular region of the mouse thalamus.

Spectrum

Sensory gatekeeper drives seizures, autism-like behaviors in mouse model

By Diana Kwon

11 September 2025 | 5 min listen

Explore more from The Transmitter

Illustration of human figures holding brightly colored connected dots.

This paper changed my life

This paper changed my life: Dan Goodman on a paper that reignited the field of spiking neural networks

By Dan Goodman

17 September 2025 | 5 min read

Connectome

First nerve-net connectome shows how evolutionarily ancient nervous system coordinates movement

By Siddhant Pusdekar

16 September 2025 | 0 min watch

Sheet of paper curled in half with a red pencil puncturing it through side of the crease.

Publishing

Paper by memory institute director garners expression of concern over image integrity

By Lauren Schneider

16 September 2025 | 5 min read