Prosocial effects of oxytocin are state dependent; and more

Here is a roundup of autism-related news and research spotted around the web for the week of 11 August.

Social support: Oxytocin’s effects on social behavior depend on ongoing social motivation and brain activity in two regions known to contribute to social reward, according to a new study in rhesus macaques. When these monkeys showed socially motivated behavior—sharing juice—an injection of oxytocin directly into the basolateral amygdala extended the duration of that prosocial state and increased neural activity between the amygdala and the anterior cingulate cortex. But when monkeys were not behaving in a prosocial way, the hormone had little effect on either behavior or neural activity. The findings may explain the variability observed in studies of oxytocin in autistic adults. Previous work has shown that vasopressin, a structurally similar hormone, improves sociability in rhesus monkeys. Journal of Neuroscience

More autism research we spotted:

  • “Pangenome discovery of missing autism variants” medRxiv
  • “SCN2A-linked myelination deficits and synaptic plasticity alterations drive auditory processing disorders in an ASD mouse model” Nature Communications
Research image of mouse auditory brainstems.
Faulty insulation: Mice missing the autism-linked gene SCN2A (right) have less myelin within axon bundles in the auditory brainstem than control mice do (left).

Sign up for the weekly Spectrum newsletter.

Stay current with the latest advancements in autism research.