News / Spectrum

SYNGAP1; executive function; synaptic density

Here is a roundup of autism-related news and research spotted around the web for the week of 14 October.

By Jill Adams
15 October 2024 | 2 min read
comments
https://doi.org/10.53053/PHEZ7464 https://doi.org/10.53053/PHEZ7464 - opens a new tab Cite this article
  • In mice, SYNGAP1 haploinsufficiency affects indirect neuronal pathways in the striatum more than direct pathways. Spectrum covered the state of the science of SYNGAP1 last year. Journal of Neuroscience
  • The timing of neurodevelopmental gene expression, derived from single-cell atlases, is a cell-specific and dynamic process. Experimental & Molecular Medicine
  • People with 3q29 deletion syndrome, which is linked to neurodevelopmental conditions, have global deficits in executive function that do not correlate with IQ scores. Psychological Medicine
  • Neuronal synapses in autistic adults have reduced density, as measured with PET scans, and lowered synaptic density correlates with a greater number of autistic features. Spectrum recently reported on the altered balance of excitatory and inhibitory synapses in autism. Molecular Psychiatry
Research image of brain scans showing the density of neuronal synapses.
Counting connections: The density of neuronal synapses in autistic people is altered in many brain regions (colored areas) compared with that in nonautistic people.
  • Autistic children and teenagers with anxiety are more likely to also have depression and problems with peers than are those without anxiety. Spectrum has covered differences in the fear centers of the brain in youth with autism and anxiety. BMC Psychology
  • The presence and severity of autism traits may change throughout childhood. Social affect scores are most likely to improve, whereas restricted and repetitive behaviors are the most likely to stay the same. Spectrum has previously covered life trajectories in autism. Autism Research

Sign up for the weekly Spectrum newsletter.

Stay current with the latest advancements in autism research.

Recommended reading

Research image of neurite overgrowth in cells grown from people with autism-linked PPP2R5D variants.
Spectrum

Cortical structures in infants linked to future language skills; and more

By Jill Adams
20 May 2025 | 2 min read
Seattle skyline.
Spectrum Microphone

Reporter’s notebook: Highlights from INSAR 2025

By Daisy Yuhas
15 May 2025 | 6 min listen
Illustration of an open journal featuring lines of text and small illustrations of eyes and mouths.
Spectrum

SHANK2 variants in people; and more

By Jill Adams
13 May 2025 | 1 min read

Explore more from The Transmitter

By clicking to watch this video, you agree to our privacy policy.
Brain Inspired Microphone

John Beggs unpacks the critical brain hypothesis

By Paul Middlebrooks
21 May 2025 | 94 min listen
Photograph of the BRIDGE team and students visiting a laboratory.
Q&A

Sharing Africa’s brain data: Q&A with Amadi Ihunwo

By Lauren Schenkman
20 May 2025 | 6 min read
Digitally distorted building blocks.
NeuroAI

The BabyLM Challenge: In search of more efficient learning algorithms, researchers look to infants

By Alona Fyshe
19 May 2025 | 7 min read