Defining cell types

Recent articles

This series explores how new high-throughput technologies are changing the way we define brain-cell types—and the challenges that remain.

A playful cellular map features top-down and bottom-up views of the human brain arranged side-by-side as if they were the earth’s two hemispheres in an old-fashioned map of the world. The brains are colored to suggest land masses and bodies of water.

Knowledge graphs can help make sense of the flood of cell-type data

These tools, widely used in the technology industry, could provide a foundation for the study of brain circuits.

By Michael Hawrylycz
28 May 2024 | 7 min read
Illustration of neurons against a blue background.

Where do cell states end and cell types begin?

High-throughput transcriptomics offers powerful new methods for defining different types of brain cells. But we need to think more explicitly about how we use these data to distinguish a cell’s permanent identity from its transient states.

By Anne E. West
22 April 2024 | 6 min read
An illustration of a gold circle and wavy blue plants.

Building a brain: How does it generate its exquisite diversity of cells?

High-throughput technologies have revealed new insights into how the brain develops. But a truly comprehensive map of neurodevelopment requires further advances.

By Tomasz Nowakowski, Karthik Shekhar
18 March 2024 | 6 min read
A diagram of many types of cells

Welcome to the second single-cell revolution: New high-throughput technologies are transforming how we define neurons

This ongoing essay series will explore questions these technologies raise, as well as opportunities they provide for understanding development, evolution and disease.

By Joshua R. Sanes
29 January 2024 | 7 min read

Get notified every time a new column in this series is published.

Explore more from The Transmitter

Computer-generated illustration of a brain in a broken jar.

Breaking the jar: Why NeuroAI needs embodiment

Brain function is inexorably shaped by the body. Embracing this fact will benefit computational models of real brain function, as well as the design of artificial neural networks.

By Bing Wen Brunton, John Tuthill
21 July 2025 | 11 min listen
US dollar bills arranged in a circle.

Quantifying funding sources across neuroscience labs

We want to hear from you about the sources of funding for your research.

By Claudia López Lloreda
18 July 2025 | 1 min read
A disembodied arm holds a megaphone.

What kinds of support do early-career researchers need?

Help The Transmitter and Neuromatch bolster the next generation of neuroscientists.

By The Transmitter, Neuromatch
18 July 2025 | 1 min read