Brain size

Recent articles

Black-and-white research image of brain organoids.

Brain organoid size matches intensity of social problems in autistic people

Overgrown organoids could point to mechanisms underlying profound autism.

By Holly Barker
18 July 2024 | 5 min read
Research image of two fluorescent-stained organoids.

CRISPR gives autism-linked genes a boost, rescues functioning

A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.

By Giorgia Guglielmi
23 May 2024 | 5 min read
A research image of autism-linked genes.

Autism-linked perturbations converge on cell skeleton and RNA-binding proteins

The findings solidify the idea that autism-linked mutations affect brain activity by way of several key shared mechanisms.

By Giorgia Guglielmi
29 February 2024 | 4 min read

Common genetic variants shape the structure of the cortex

A genome-wide association study lays a foundation for deeper investigation of these variants in neurodevelopmental conditions.

By Lauren Schenkman
18 September 2023 | 6 min listen
Research image of organoids in the forebrain.

Head size parts autism into two major subtypes

An imbalance in the number of excitatory neurons in early brain development may account for the difference.

By Charles Q. Choi
12 September 2023 | 4 min read
Illustration of half of a brain on the left and half of a heart on the right

Change of heart and mind: Autism’s ties to cardiac defects

Children with congenital heart disease have an increased likelihood of autism. Why?

By Lauren Schenkman
21 July 2023 | 12 min read
Composite research image of organoids at several stages of development.

Genetic background sways effects of autism-linked mutation

Experiments offer clues to why certain mutations are associated with autism in some people and not others.

By Charles Q. Choi
18 May 2023 | 4 min read
Research image of zebrafish forebrains.

Autism-related genes converge on microglia and dopamine in zebrafish

The findings add to the growing evidence that genes with disparate functions can play similar roles in brain development.

By Peter Hess
12 May 2023 | 4 min read
Research image of the blood-brain barrier.

Rare autism-linked mutation starves growing neurons of essential nutrients

The mutation prevents certain amino acids from entering neurons, causing the cells to die early in development.

By Lauren Schenkman
10 April 2023 | 5 min read
Three scans of zebrafish brains.

Zebrafish point to new gene involved in brain overgrowth, autism

The gene, YTHDF2, has not previously been linked to autism.

By Katharine Gammon
1 November 2022 | 2 min read

Explore more from The Transmitter

Imagining the ultimate systems neuroscience paper

A growing body of papers on systems neuroscience and on giant simulations of neural circuits involves data beyond the point that anyone can reasonably understand end to end. Looking ahead, “paper-bots” could solve that problem.

By Mark Humphries
2 December 2024 | 8 min read
Illustration of a pen hovering over a gene sequence-like series of colored rectangles.

This paper changed my life: ‘Histone demethylation mediated by the nuclear amine oxidase homolog LSD1,’ from the Shi Lab

This paper defined key rules of epigenomic regulation and shaped how I study chromatin plasticity as a mechanism for experience-dependent changes in the brain.

By Anne E. West
27 November 2024 | 5 min read

What’s next for brain-directed gene therapy after death in Neurogene trial

The incident highlights that viral vectors can trigger deadly immune responses even when delivered directly to the nervous system.

By Calli McMurray
26 November 2024 | 6 min read