The HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required) funding from the National Institutes of Health (NIH) supports clinical trials that test new and improved integrated approaches for people who have both chronic pain and opioid use disorder (OUD).
Studies must combine clinical intervention research with implementation science through hybrid implementation-effectiveness designs, aiming to improve the reach, scalability, and sustainability of integrated care within health systems.
Applications are open to organizations based in the United States. Each application must propose a single clinical trial with participants who have both chronic pain and OUD, and must include an Evidence-to-Action Partner engagement plan, an OUD and Pain Partner engagement plan, and pilot projects.
The funding provides up to 900,000 USD per year for direct costs, plus indirect costs. The maximum project period is 5 years.
Opportunity number: RFA-DA-28-011
Applications open on December 26, 2026, and close on January 26, 2027.