Methods
Recent articles
Claims of necessity and sufficiency are not well suited for the study of complex systems
The earliest studies on necessary and sufficient neural populations were performed on simple invertebrate circuits. Does this logic still serve us as we tackle more sophisticated outputs?

Claims of necessity and sufficiency are not well suited for the study of complex systems
The earliest studies on necessary and sufficient neural populations were performed on simple invertebrate circuits. Does this logic still serve us as we tackle more sophisticated outputs?
Plaque levels differ in popular Alzheimer’s mouse model depending on which parent’s variants are passed down
5XFAD model mice that inherit two disease-related genes from their fathers have double the plaques seen in those with maternal inheritance, a new study shows.
Plaque levels differ in popular Alzheimer’s mouse model depending on which parent’s variants are passed down
5XFAD model mice that inherit two disease-related genes from their fathers have double the plaques seen in those with maternal inheritance, a new study shows.
Protocol-sharing site aims to ease administrative burden of animal research
The library of regulatory-compliant animal procedures offers experimental standards and specific language that researchers can borrow for their own legal paperwork.

Protocol-sharing site aims to ease administrative burden of animal research
The library of regulatory-compliant animal procedures offers experimental standards and specific language that researchers can borrow for their own legal paperwork.
Digitization of ‘breathtaking’ neuroanatomy slide collection offers untapped research gold mine
Thousands of histological sections of vertebrate brains—including from spiny dogfish, turtles and more—are newly available online.

Digitization of ‘breathtaking’ neuroanatomy slide collection offers untapped research gold mine
Thousands of histological sections of vertebrate brains—including from spiny dogfish, turtles and more—are newly available online.
David Krakauer reflects on the foundations and future of complexity science
In his book “The Complex World,” Krakauer explores how complexity science developed, from its early roots to the four pillars that now define it—entropy, evolution, dynamics and computation.
David Krakauer reflects on the foundations and future of complexity science
In his book “The Complex World,” Krakauer explores how complexity science developed, from its early roots to the four pillars that now define it—entropy, evolution, dynamics and computation.
Spectrum 2024: Year in review
We round up our most notable autism stories of the past 12 months.

Spectrum 2024: Year in review
We round up our most notable autism stories of the past 12 months.
The non-model organism “renaissance” has arrived
Meet 10 neuroscientists bringing model diversity back with the funky animals they study.

The non-model organism “renaissance” has arrived
Meet 10 neuroscientists bringing model diversity back with the funky animals they study.
Solving intelligence requires new research and funding models
Our research ecosystem isn't built to deliver the breakthroughs needed to understand intelligence at scale. We need a dedicated research institution to take up the task.

Solving intelligence requires new research and funding models
Our research ecosystem isn't built to deliver the breakthroughs needed to understand intelligence at scale. We need a dedicated research institution to take up the task.
Imagining the ultimate systems neuroscience paper
A growing body of papers on systems neuroscience and on giant simulations of neural circuits involves data beyond the point that anyone can reasonably understand end to end. Looking ahead, “paper-bots” could solve that problem.

Imagining the ultimate systems neuroscience paper
A growing body of papers on systems neuroscience and on giant simulations of neural circuits involves data beyond the point that anyone can reasonably understand end to end. Looking ahead, “paper-bots” could solve that problem.
To keep or not to keep: Neurophysiology’s data dilemma
An exponential growth in data size presents neuroscientists with a significant challenge: Should we be keeping all raw data or focusing on processed datasets? I asked experimentalists and theorists for their thoughts.

To keep or not to keep: Neurophysiology’s data dilemma
An exponential growth in data size presents neuroscientists with a significant challenge: Should we be keeping all raw data or focusing on processed datasets? I asked experimentalists and theorists for their thoughts.
Explore more from The Transmitter
Why hasn’t genetics taught us more about schizophrenia?
Large-scale genomics studies have failed to identify specific pathways that go awry in schizophrenia. Alternative approaches focusing on cellular, molecular and systems-level changes may be needed.

Why hasn’t genetics taught us more about schizophrenia?
Large-scale genomics studies have failed to identify specific pathways that go awry in schizophrenia. Alternative approaches focusing on cellular, molecular and systems-level changes may be needed.
Depression perception; MYT1L mice; brain signal variability
Here is a roundup of autism-related news and research spotted around the web for the week of 17 February.

Depression perception; MYT1L mice; brain signal variability
Here is a roundup of autism-related news and research spotted around the web for the week of 17 February.
Does the solution to building safe artificial intelligence lie in the brain?
Now is the time to decipher what makes the brain both flexible and dependable—and to apply those lessons to AI—before an unaligned agentic system wreaks havoc.

Does the solution to building safe artificial intelligence lie in the brain?
Now is the time to decipher what makes the brain both flexible and dependable—and to apply those lessons to AI—before an unaligned agentic system wreaks havoc.