Microscopy

Recent articles

New tissue-clearing techniques let microscopes peer deeper into living brains

Washing mouse brain tissue with a blood protein or complex sugar can illuminate cells 550 micrometers into the cortex without compromising its normal physiology.

By Calli McMurray
18 October 2024 | 0 min watch

Octopus arm anatomy, molecular makeup revealed in new maps

The datasets provide “a very nice reference” for future functional studies.

By Calli McMurray
25 September 2024 | 1 min watch
A dense reconstruction of layer 2/3 neurons of the mouse visual cortex containing 394 neurons and 3.2 million synapses.

To develop better nervous-system visualizations, we need to think BIG

With a full mouse connectome on the horizon, neuroscience needs to overcome its legacy of minimalism and embrace the contemporary challenge of representing whole-nervous-system connectivity.

By Tyler Sloan
8 July 2024 | 8 min read
Image of neural activity in a mouse as seen through the Miniscope.

Designing an open-source microscope

Funding for the development of open-source tools is on the rise, but support for their maintenance and dissemination, both crucial for their meaningful uptake, remains a major challenge.

By Daniel Aharoni
17 June 2024 | 6 min read

Getting musical to spot patterns in whole-brain imaging data: Q&A with Elizabeth Hillman

The new technique takes advantage of humans’ “extraordinary” sensory processing abilities, Hillman says.

By Calli McMurray
21 February 2024 | 0 min watch

Robotic headgear records brain activity in moving mice

The tool could help researchers study the neurobiology of natural behaviors, scientists say.

By Holly Barker
3 August 2023 | 5 min read

Explore more from The Transmitter

Research image of a fiber optic implant in a mouse brain.

Bespoke photometry system captures variety of dopamine signals in mice

The tool tracks the excitation of an engineered protein that senses dopamine’s absolute levels, including fast and slow fluctuations in real time, and offers new insights into how the signals change across the brain.

By Sydney Wyatt
21 March 2025 | 5 min read
Cognitive neuroscientist Nick Turk-Browne helps an infant into an fMRI machine.

What infant fMRI is revealing about the developing mind

Cognitive neuroscientists have finally clocked how to perform task-based functional MRI experiments in awake babies—long known for their inability to lie still or take direction. Next, they aim to watch cognition take shape and settle a debate about our earliest memories—with one group publishing a big clue today.

By Calli McMurray
20 March 2025 | 12 min read
A mouse sits on a gloved hand.

Molecular changes after MECP2 loss may drive Rett syndrome traits

Knocking out the gene in adult mice triggered up- and down-regulated expression of myriad genes weeks before there were changes in neuronal function.

By Chloe Williams
20 March 2025 | 5 min read