Neurodegenerative disorders
Recent articles
Everything, everywhere, all at once: Inside the chaos of Alzheimer’s disease
To truly understand Alzheimer’s disease, we may need to take a systems approach, in which inflammation, vascular injury, impaired glucose metabolism and other factors interact in complex ways.
Everything, everywhere, all at once: Inside the chaos of Alzheimer’s disease
To truly understand Alzheimer’s disease, we may need to take a systems approach, in which inflammation, vascular injury, impaired glucose metabolism and other factors interact in complex ways.
The brain’s quiet conductor: How hidden cells fine-tune arousal
New research published today suggests that the pericoeruleus acts as a kind of micromanager of arousal, selectively inhibiting different subgroups of locus coeruleus neurons depending on the behavioral context.
The brain’s quiet conductor: How hidden cells fine-tune arousal
New research published today suggests that the pericoeruleus acts as a kind of micromanager of arousal, selectively inhibiting different subgroups of locus coeruleus neurons depending on the behavioral context.
In vivo veritas: Xenotransplantation can help us study the development and function of human neurons in a living brain
Transplanted cells offer insight into human-specific properties, such as a lengthy cortical development and sensitivity to neurodevelopmental and neurodegenerative disease.
In vivo veritas: Xenotransplantation can help us study the development and function of human neurons in a living brain
Transplanted cells offer insight into human-specific properties, such as a lengthy cortical development and sensitivity to neurodevelopmental and neurodegenerative disease.
Early trajectory of Alzheimer’s tracked in single-cell brain atlases
Inflammation in glia and the loss of certain inhibitory cells may kick off a disease cascade decades before diagnosis.
Early trajectory of Alzheimer’s tracked in single-cell brain atlases
Inflammation in glia and the loss of certain inhibitory cells may kick off a disease cascade decades before diagnosis.
Brains, biases and amyloid beta: Why the female brain deserves a closer look in Alzheimer’s research
New results suggest the disease progresses differently in women, but we need more basic science to unpack the mechanisms involved.
Brains, biases and amyloid beta: Why the female brain deserves a closer look in Alzheimer’s research
New results suggest the disease progresses differently in women, but we need more basic science to unpack the mechanisms involved.
Timothy Ryan on his pivotal switch from studying particle physics to decoding synaptic transmission
Dissuaded from pursuing theoretical physics and deterred by the “long feedback loop” in experimental physics, the National Academy of Sciences member took inspiration from “polymath” Watt Webb and “visionary” Stephen Smith—and learned to work “completely outside his comfort zone.”
Timothy Ryan on his pivotal switch from studying particle physics to decoding synaptic transmission
Dissuaded from pursuing theoretical physics and deterred by the “long feedback loop” in experimental physics, the National Academy of Sciences member took inspiration from “polymath” Watt Webb and “visionary” Stephen Smith—and learned to work “completely outside his comfort zone.”
Six new neuroscience books for fall—plus five titles you may have missed
We highlight the most anticipated neuroscience books for the remainder of 2024 and recap notable releases since last December.
Six new neuroscience books for fall—plus five titles you may have missed
We highlight the most anticipated neuroscience books for the remainder of 2024 and recap notable releases since last December.
Supersized version of Alzheimer’s protein avoids clumping in brain
“Big tau” may explain why some brain regions, such as the cerebellum and brainstem, are largely spared from neurodegeneration, even though tau is expressed throughout the nervous system.
Supersized version of Alzheimer’s protein avoids clumping in brain
“Big tau” may explain why some brain regions, such as the cerebellum and brainstem, are largely spared from neurodegeneration, even though tau is expressed throughout the nervous system.
Carol Jennings, whose family’s genetics informed amyloid cascade hypothesis, dies at 70
Her advocacy work aided the discovery of a rare inherited form of early-onset Alzheimer’s disease and helped connect affected people with researchers.
Carol Jennings, whose family’s genetics informed amyloid cascade hypothesis, dies at 70
Her advocacy work aided the discovery of a rare inherited form of early-onset Alzheimer’s disease and helped connect affected people with researchers.
Explore more from The Transmitter
Worms help untangle brain structure/function mystery
The synaptic connectome of most animals bears little resemblance to functional brain maps, but it can still predict neuronal activity, according to two preprints that tackle the puzzle in C. elegans.
Worms help untangle brain structure/function mystery
The synaptic connectome of most animals bears little resemblance to functional brain maps, but it can still predict neuronal activity, according to two preprints that tackle the puzzle in C. elegans.
Microglia nurture young interneurons
The immune cells secrete a growth factor that “sets the supply of GABAergic interneurons in the developing brain.”
Microglia nurture young interneurons
The immune cells secrete a growth factor that “sets the supply of GABAergic interneurons in the developing brain.”
Xaq Pitkow shares his principles for studying cognition in our imperfect brains and bodies
Pitkow discusses how evolution's messy constraints shape optimal brain algorithms, from Bayesian inference to ecological affordances.
Xaq Pitkow shares his principles for studying cognition in our imperfect brains and bodies
Pitkow discusses how evolution's messy constraints shape optimal brain algorithms, from Bayesian inference to ecological affordances.