Seizures

Recent articles

Research image of SCN2A neurons.

Boosting SCN2A expression reduces seizures in mice

A modified form of CRISPR amps up expression of the gene—a strategy that could apply to other gene variations linked to autism.

By Charles Q. Choi
9 October 2025 | 5 min read
Stack of papers.

Exclusive: The 23 studies the FDA based its expanded leucovorin label on

The studies include 46 people, mostly toddlers, who have cerebral folate deficiency due to variants in a folate transporter.

By Claudia López Lloreda
2 October 2025 | 6 min read
Research image of two mouse brain slices.

Split gene therapy delivers promise in mice modeling Dravet syndrome

The new approach overcomes viral packaging limitations by delivering SCN1A piecemeal and stitching it together in target cells.

By Holly Barker
10 April 2025 | 5 min read
Research image of brain scans.

Impaired molecular ‘chaperone’ accompanies multiple brain changes, conditions

Rare genetic variants in a protein-folding complex contribute to a spectrum of phenotypes that encompass brain malformations, intellectual disability, autism and seizures, according to a new “hallmark” study.

By Holly Barker
12 December 2024 | 5 min read

Widely used calcium imaging protocol can lead to spurious results, new paper cautions

The technique, which measures calcium currents as a proxy for neuronal firing, sometimes reports unusual and potentially misleading waves of activity in the hippocampus.

By Angie Voyles Askham
19 June 2024 | 0 min watch
Research image of neurons in a small section of the hippocampus.

Tail of hippocampus may be hub for seizures in mice and people

This little-studied subregion, called the fasciola cinereum, could be a new surgical target for people with treatment-resistant epilepsy.

By Shaena Montanari
14 June 2024 | 4 min read
Research image of antisense oligonucleotides.

RNA drug corrects calcium signaling in chimeric model of Timothy syndrome

The drug, tested in rats that have human neurons, could enter clinical testing as early as next year, researchers say.

By Katie Moisse
24 April 2024 | 5 min read
Top down view of a slice of a rat brain connected to an output camera.

On a bold mission to re-engineer brain parts

A European consortium is on a quest to restore typical brain activity in people with epilepsy, using a mash-up of custom organoids, microelectronics and artificial intelligence.

By Rebecca Horne
24 January 2024 | 1 min read
A hand points to an illustration on a chalkboard.

From a scientist’s perspective: The Transmitter’s top five essays in 2023

From big-picture debates about theories and terms to practical tips for teaching and writing, our favorite expert-written articles offer a glimpse into what neuroscientists are thinking.

By The Transmitter
25 December 2023 | 3 min read
Illustration of a meteorologist pointing to an aerial view of clouds swirling over a brain-shaped land mass.

Is the brain uncontrollable, like the weather?

The brain may be chaotic. Does that mean our efforts to control it are doomed?

By Nicole Rust
18 December 2023 | 10 min read

Explore more from The Transmitter

Nikolay Kukushkin discusses his book, ‘One Hand Clapping: Unraveling the Mystery of the Human Mind’

He explains how meaning arises in the interactions found throughout nature and evolution, from molecules to minds.

By Paul Middlebrooks
8 October 2025 | 1 min read
Research image of neurons with variants of the KCNQ2 gene (bottom row) developing more synaptic protein groups (pink and blue) than control neurons (top row).

ADSI, leucovorin, autism registry; and more

Here is a roundup of autism-related news and research spotted around the web for the week of 6 October.

By Jill Adams
7 October 2025 | 2 min read
A drosophila connectome.

One year of FlyWire: How the resource is redefining Drosophila research

We asked nine neuroscientists how they are using FlyWire data in their labs, how the connectome has transformed the field and what new tools they would like to see in the future.

By Francisco J. Rivera Rosario
7 October 2025 | 19 min listen

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