The big picture

Recent articles

Researchers ask colleagues to weigh in on important topics in the field.

Data streams into a transparent box.

Accepting “the bitter lesson” and embracing the brain’s complexity

To gain insight into complex neural data, we must move toward a data-driven regime, training large models on vast amounts of information. We asked nine experts on computational neuroscience and neural data analysis to weigh in.

By Eva Dyer, Blake Richards
26 March 2025 | 8 min read
Illustration of a funnel taking abstract shapes in at the top and spouting an organized flow of shapes out at the bottom.

To keep or not to keep: Neurophysiology’s data dilemma

An exponential growth in data size presents neuroscientists with a significant challenge: Should we be keeping all raw data or focusing on processed datasets? I asked experimentalists and theorists for their thoughts.

By Nima Dehghani
25 November 2024 | 5 min read
Illustration of an image of a landscape repeated over and over again, with some versions distorted and warped.

What makes memories last—dynamic ensembles or static synapses?

Teasing out how different subfields conceptualize central terms might help move this long-standing debate forward. I asked eight scientists to weigh in.

By Jason Shepherd
14 October 2024 | 7 min read
Collage of different images of brains and mechanical devices in the background with a suitcase in the foreground.

What are mechanisms? Unpacking the term is key to progress in neuroscience

Mechanism is a common and powerful concept, invoked in grant calls and publication guidelines. But scientists use it in different ways, making it difficult to clarify standards in the field. We asked nine scientists to weigh in.

By Dani S. Bassett, Lauren N. Ross
7 October 2024 | 5 min read
Illustration of a sparkly brain.

What, if anything, makes mood fundamentally different from memory?

To better understand mood disorders—and to develop more effective treatments—should we target the brain, the mind, the environment or all three?

By Nicole Rust
8 April 2024 | 8 min read
Illustration of a meteorologist pointing to an aerial view of clouds swirling over a brain-shaped land mass.

Is the brain uncontrollable, like the weather?

The brain may be chaotic. Does that mean our efforts to control it are doomed?

By Nicole Rust
18 December 2023 | 10 min read

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Explore more from The Transmitter

Illustration of a musical staff with notes represented by neurons.

This paper changed my life: Abigail Person on birdsong, feed-forward circuits and convergent computations

By isolating specific neuron types involved in zebra finch birdsong, this 2002 Nature paper from Michael Fee and colleagues revealed elegant neural mechanisms controlling the timing of natural learned behavior.

By Abigail Person
12 August 2025 | 6 min listen
Research image of mouse auditory brainstems.

Prosocial effects of oxytocin are state dependent; and more

Here is a roundup of autism-related news and research spotted around the web for the week of 11 August.

By Jill Adams
12 August 2025 | 2 min read
A series of colored rectangles in a cosmos-like black space.

The challenge of defining a neural population

Our current approach is largely arbitrary. We need new methods for grouping cells, ideally by their dynamics.

By Mark Humphries
11 August 2025 | 9 min listen