Excitability

Recent articles

Research image of mouse brain slices stained in red and blue.

Ramping up cortical activity in early life sparks autism-like behaviors in mice

The findings add fuel to the long-running debate over how an imbalance in excitatory and inhibitory signaling contributes to the autism.

By Sarah DeWeerdt
30 October 2025 | 6 min read
Research image of different interneuron subtypes responding to the absence of pyramidal neurons in the mouse cortex.

As circuits wire up, interneurons take cues from surrounding cells

The inhibitory cells’ development, diversity and abundance in the cortex is directed in part by pyramidal cells, a new preprint suggests.

By Olivia Gieger
14 August 2024 | 5 min read
A research image of neuronal dendrites in mice.

Top autism-linked genes join forces to shape synaptic plasticity

The protein products of ANK2 and SCN2A interact to regulate dendritic excitability.

By Holly Barker
29 January 2024 | 4 min read

Explore more from The Transmitter

Among brain changes studied in autism, spotlight shifts to subcortex

The striatum and thalamus are more likely than the cerebral cortex to express autism variants or bear transcriptional changes, two unpublished studies find.

By Holly Barker
11 December 2025 | 5 min read
Brain organoid.

What is the future of organoid and assembloid regulation?

Four experts weigh in on how to establish ethical guardrails for research on the 3D neuron clusters as these models become ever more complex.

By Claudia López Lloreda
10 December 2025 | 7 min read
Research image of variants of the ATPase subunit PSMC5/RPT6.

Insights on suicidality and autism; and more

Here is a roundup of autism-related news and research spotted around the web for the week of 8 December.

By Jill Adams
9 December 2025 | 2 min read

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