Female protective effect

Recent articles

Research image highlighting different brain regions.

X marks the spot in search for autism variants

Genetic variants on the X chromosome, including those in the gene DDX53, contribute to autism’s gender imbalance, two new studies suggest.

By Holly Barker
16 January 2025 | 6 min read
Illustration of children looking at a gigantic set of building blocks, some of which display genetic sequences on their surfaces.

Autism is more heritable in boys than in girls

If boys have greater inherited liability for autism, the female protective effect may not fully explain the sex difference in prevalence.

Research illustration groups genes by their effects on brain cell types.

Giant analysis reveals how autism-linked genes affect brain cell types

Genes that predispose people to autism account for a large portion of the neuronal and glial cell changes seen in those with the condition.

By Charles Q. Choi
20 June 2024 | 5 min read
Composite research image of organoids at several stages of development.

Genetic background sways effects of autism-linked mutation

Experiments offer clues to why certain mutations are associated with autism in some people and not others.

By Charles Q. Choi
18 May 2023 | 4 min read
Illustration of an X chromosome against a black background.

X-chromosome variants help explain autism’s sex bias

The rare variants are also linked to ADHD and Tourette syndrome, two other conditions that disproportionately affect boys and men.

By Charles Q. Choi
24 October 2022 | 4 min read

Explore more from The Transmitter

Illustration of an open journal featuring lines of text and small illustrations of eyes and mouths.

Autism-linked genes alter sleep behavior, and more

Here is a roundup of autism-related news and research spotted around the web for the week of 13 April.

By Jill Adams
14 April 2026 | 2 min read
Illustration of a monkey pushing a button.

This paper changed my life: Erin Calipari ponders the nuances of rewarding and aversive stimuli

A 1960s study by Kelleher and Morse found that lever pressing in squirrel monkeys depended not on whether they received a reward or shock, but on the rules of the task. This taught Calipari to think deeply about factors that influence how behavior is generated and maintained.

By Erin Calipari
14 April 2026 | 5 min read
Illustration of a sheet of paper with a topography map-like pattern on it.

Why neural foundation models work, and what they might—and might not—teach us about the brain

These models can partly generalize across species, brain regions and tasks, suggesting that a set of machine-learnable rules govern neural population activity. But will we be able to understand them?

By Juan Gallego
13 April 2026 | 8 min read