FMR1

A research image of X chromosomes with Fragile X syndrome

Understanding fragile X syndrome

Just in time for Fragile X Awareness Month, The Transmitter rounds up notable coverage.

By Daisy Yuhas
4 July 2024 | 2 min read
Two hands hold a mouse.

Noisy brain may underlie some of autism’s sensory features

Random fluctuations in neuronal activity are more variable in a fragile X mouse model than in wildtype mice.

By Holly Barker
18 January 2024 | 6 min read
Research image of neurons in mice.

Skewed signaling in striatum may spawn repetitive behaviors

Synaptic changes in the brain region could drive a core trait of fragile X syndrome, a new mouse study suggests.

By Holly Barker
6 September 2023 | 3 min read
Research images of protein synthesis in mice.

Neuronal deafness to stress may add to protein surplus in fragile X

A protective pathway that pauses protein synthesis is muted in a mouse model of fragile X syndrome, according to a new study.

By Holly Barker
29 August 2023 | 3 min listen

Unknown isoform adds twist to theory of fragile X origins

Contrary to conventional wisdom, most people with fragile X syndrome express the FMR1 gene — albeit improperly.

By Holly Barker
11 July 2023 | 6 min read
Illustration of a fragile X syndrome chromosome.
Genes Microphone

New gene-editing method flags fragile X mutation for repair

The approach prompts cultured cells to correct the genetic mutation in fragile X syndrome using their own DNA repair system, but it still needs to be tested further.

By Angie Voyles Askham
5 July 2023 | 5 min listen
Research image of neurons and astrocytes.

Astrocytes fuel erratic firing in fragile X neurons

A shift in astrocyte secretions may explain the atypical firing patterns of neurons derived from people with fragile X syndrome.

By Lauren Schenkman
10 May 2023 | 5 min read
An illustration of a scientist on a stage with a giant pill bottle that has been chopped in half.

Company on brink takes psilocybin to trial for fragile X syndrome

The phase 2A trial has its detractors despite positive animal results and is being sponsored by a company that is struggling financially.

By Peter Hess
25 April 2023 | 9 min listen
Illustration of a sheet of red and white pills, with the red pills arranged in the form of a question mark.

Going on Trial: Orphan drugs; CBD; bumetanide

This month’s newsletter takes a close look at the orphan drug program in the United States, several cannabis-based therapies and a secondary analysis of bumetanide, among other new developments in autism-related drug trials.

By Peter Hess
28 February 2023 | 7 min read
an image of a neuron
Spectrum Microphone

Neurons struggle to spike without fragile X gene

FMR1 loss impairs sodium channels, hindering mouse neurons from generating the electrical signals needed to transmit information.

By Laura Dattaro
17 February 2023 | 3 min read

Explore more from The Transmitter

Brain organoid size matches intensity of social problems in autistic people

Overgrown organoids could point to mechanisms underlying profound autism.

By Holly Barker
18 July 2024 | 5 min read

Persistent protein pairing enables memories to last

The complex of two memory proteins, rather than the individual molecules acting independently, underlie month-long memories in mice, a new study suggests.

By Elissa Welle
17 July 2024 | 5 min read
A digitally distorted image of a file folder against a blue gradient background.

Data access changes to UK Biobank stir unease in neuroscientists

“I feel a little bit in limbo,” says neuroscientist Stephanie Noble, who has paused a study using Biobank data after the repository shifted from a data download to a cloud-only access model.

By Calli McMurray
16 July 2024 | 7 min read