GWAS

Illustration of a brain made up of many smaller brains.
fMRI Microphone

Breaking down the winner’s curse: Lessons from brain-wide association studies

We found an issue with a specific type of brain imaging study and tried to share it with the field. Then the backlash began.

By Nico Dosenbach, Scott Marek
25 March 2024 | 7 min listen
Brain imaging Microphone

Common genetic variants shape the structure of the cortex

A genome-wide association study lays a foundation for deeper investigation of these variants in neurodevelopmental conditions.

By Lauren Schenkman
18 September 2023 | 5 min listen
Research diagram of gene clusters.

Atlas of gene activity in prenatal brain holds clues to autism

Genes exert their strongest influence on the brain in the first half of gestation — a key window for autism and other neurodevelopmental conditions.

By Brendan Borrell
24 April 2023 | 4 min read
Illustration of a room with DNA sequence wallpaper and three doors leading to abstract new environments.

The future of autism therapies: A conversation with Lilia Iakoucheva and Derek Hong

If a therapy for autism’s core traits makes it to market, it will likely take one of three forms, the researchers say.

By Peter Hess
14 April 2023 | 5 min read
MRI scan of a 2-year-old child.

Mapping genetic influences on the infant brain: A chat with Rebecca Knickmeyer

Researchers know little about the ways genetic variants affect development in the infant brain. Knickmeyer, who launched the Organization for Imaging Genomics in Infancy, has spent the past five years trying to close the gap.

By Laura Dattaro
27 February 2023 | 6 min read
A pattern in the style of genetic sequencing forms into the shape of the African continent.

Africa’s genomic role: Q&A with Conrad Iyegbe and Niran Okewole

Psychiatric genomics promises to shed light on the genetic basis of autism, but it’s vital to include Africa in this research, Iyegbe and Okewole say.

By Charles Q. Choi
28 November 2022 | 7 min read
Conceptual illustration of a door leading from one area of the brain to another area of the brain.
Spectrum Microphone

Autism’s genetic heterogeneity evident in brain connectivity patterns

The results highlight the importance of subgrouping study participants based on their underlying genetics, the researchers say.

By Angie Voyles Askham
27 September 2022 | 5 min read
Spectrum Microphone

Mutations disrupting chromatin interactions contribute to autism

The mutations occur spontaneously in noncoding stretches of DNA that control gene expression.

By Giorgia Guglielmi
8 August 2022 | 5 min read
A pregnant woman and another figure are obscured by shadows.
Spectrum Microphone

Maternal genetics may confound studies of autism’s link to prenatal factors

Women who carry genetic variants tied to autism have an elevated chance of experiencing pregnancy-related events linked to the condition in their children.

By Charles Q. Choi
2 August 2022 | 5 min read
Concept illustration of DNA deletion: 2 DNA strands extend horizontally across a burnt orange background. The bottom is intact, while there are gaps in the top strand.

Deletions on chromosome 22 have ripple effects across genome

Deletion of the 22q11.2 chromosomal region alters the expression of numerous autism- and schizophrenia-linked genes, most of which are not contained within the deleted region, a new study suggests.

By Angie Voyles Askham
20 July 2022 | 5 min read

Explore more from The Transmitter

Research illustration groups genes by their effects on brain cell types.

Giant analysis reveals how autism-linked genes affect brain cell types

Genes that predispose people to autism account for a large portion of the neuronal and glial cell changes seen in those with the condition.

By Charles Q. Choi
20 June 2024 | 5 min read

Widely used calcium imaging protocol can lead to spurious results, new paper cautions

The technique, which measures calcium currents as a proxy for neuronal firing, sometimes reports unusual and potentially misleading waves of activity in the hippocampus.

By Angie Voyles Askham
19 June 2024 | 0 min watch
Research image of white-matter density in brains of people with deletions or duplications in the 16p11.2 chromosomal region.

Double-empathy problem; dup15q syndrome; myelin loss in aging autistic adults

Here is a roundup of autism-related news and research spotted around the web for the week of 17 June.

By Jill Adams
18 June 2024 | 2 min read