Macrocephaly
Recent articles
CRISPR gives autism-linked genes a boost, rescues functioning
A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.

CRISPR gives autism-linked genes a boost, rescues functioning
A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.
Head size parts autism into two major subtypes
An imbalance in the number of excitatory neurons in early brain development may account for the difference.

Head size parts autism into two major subtypes
An imbalance in the number of excitatory neurons in early brain development may account for the difference.
Genetic background sways effects of autism-linked mutation
Experiments offer clues to why certain mutations are associated with autism in some people and not others.

Genetic background sways effects of autism-linked mutation
Experiments offer clues to why certain mutations are associated with autism in some people and not others.
CHD8 mutation in 33 mouse strains yields range of traits
The findings put genetic background forward to help explain autism’s heterogeneity.

CHD8 mutation in 33 mouse strains yields range of traits
The findings put genetic background forward to help explain autism’s heterogeneity.
Excess of ‘don’t eat me’ cell signals may drive brain enlargement in autism
The signal, called CD47, is disrupted in autistic people who have a larger-than-average head.

Excess of ‘don’t eat me’ cell signals may drive brain enlargement in autism
The signal, called CD47, is disrupted in autistic people who have a larger-than-average head.
Zebrafish point to new gene involved in brain overgrowth, autism
The gene, YTHDF2, has not previously been linked to autism.

Zebrafish point to new gene involved in brain overgrowth, autism
The gene, YTHDF2, has not previously been linked to autism.
New diagnostic code for PTEN syndrome may spur research
The code may help scientists identify people with the autism-linked condition and recruit them into clinical trials.

New diagnostic code for PTEN syndrome may spur research
The code may help scientists identify people with the autism-linked condition and recruit them into clinical trials.
Different forms of autism have opposite problems with brain precursor cells
The cells’ altered proliferation rates hint at ways to diagnose and potentially treat autism earlier.

Different forms of autism have opposite problems with brain precursor cells
The cells’ altered proliferation rates hint at ways to diagnose and potentially treat autism earlier.
Novel gene linked to brain size in autistic people
The gene, YTHDF2, may be one of several that contribute to an autism subtype marked by an unusually big brain.

Novel gene linked to brain size in autistic people
The gene, YTHDF2, may be one of several that contribute to an autism subtype marked by an unusually big brain.
Organoids show how mutations in top autism gene may lead to brain overgrowth in people
The loss of CHD8, a top autism gene, speeds up the production of certain neurons and leads to overgrowth in spheres of cultured brain cells.

Organoids show how mutations in top autism gene may lead to brain overgrowth in people
The loss of CHD8, a top autism gene, speeds up the production of certain neurons and leads to overgrowth in spheres of cultured brain cells.
Explore more from The Transmitter
Why hype for autism stem cell therapies continues despite dead ends
After numerous tests, there is still no evidence that these experimental treatments help, so now is not the time to expand access to them.

Why hype for autism stem cell therapies continues despite dead ends
After numerous tests, there is still no evidence that these experimental treatments help, so now is not the time to expand access to them.
Adult human cortex does not reorganize after amputation
The results from a new longitudinal study contradict classic findings in monkeys but may not warrant a rewriting of the textbooks just yet.

Adult human cortex does not reorganize after amputation
The results from a new longitudinal study contradict classic findings in monkeys but may not warrant a rewriting of the textbooks just yet.
Remembering A. James Hudspeth, hair cell explorer
Hudspeth, who died 16 August at age 79, devoted his 50-year career to untangling how the ear converts sound into electrical signals.

Remembering A. James Hudspeth, hair cell explorer
Hudspeth, who died 16 August at age 79, devoted his 50-year career to untangling how the ear converts sound into electrical signals.