SCN2A
Recent articles
Widely used calcium imaging protocol can lead to spurious results, new paper cautions
The technique, which measures calcium currents as a proxy for neuronal firing, sometimes reports unusual and potentially misleading waves of activity in the hippocampus.
Widely used calcium imaging protocol can lead to spurious results, new paper cautions
The technique, which measures calcium currents as a proxy for neuronal firing, sometimes reports unusual and potentially misleading waves of activity in the hippocampus.
CRISPR gives autism-linked genes a boost, rescues functioning
A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.
CRISPR gives autism-linked genes a boost, rescues functioning
A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Mutation in top autism-linked gene may alter eye reflex
The discovery could help clinicians diagnose children who carry mutations in the gene, called SCN2A, and gauge their responses to potential therapies.
Mutation in top autism-linked gene may alter eye reflex
The discovery could help clinicians diagnose children who carry mutations in the gene, called SCN2A, and gauge their responses to potential therapies.
Top autism-linked genes join forces to shape synaptic plasticity
The protein products of ANK2 and SCN2A interact to regulate dendritic excitability.
Top autism-linked genes join forces to shape synaptic plasticity
The protein products of ANK2 and SCN2A interact to regulate dendritic excitability.
Autism research hits the road
Some scientists are thinking creatively about how to collect data in flexible environments and meet communities where they’re at.
Autism research hits the road
Some scientists are thinking creatively about how to collect data in flexible environments and meet communities where they’re at.
Latest ‘prime-editing’ tools tackle delivery, safety issues
The gene-editing advances make it easier to target specific tissues in mice and detect off-target effects.
Latest ‘prime-editing’ tools tackle delivery, safety issues
The gene-editing advances make it easier to target specific tissues in mice and detect off-target effects.
New evidence hints at mechanisms for ‘fever effect’ in autism
The temporary easing of traits that a minority of autistic children are reported to show during or after a fever may stem from a rise in body temperature.
New evidence hints at mechanisms for ‘fever effect’ in autism
The temporary easing of traits that a minority of autistic children are reported to show during or after a fever may stem from a rise in body temperature.
Dispatches from SfN 2021: Mitochondria, Rett therapy and oxytocin
These short reports from Spectrum journalists highlight some of the autism-related findings that caught our attention at the meeting this past week.
Dispatches from SfN 2021: Mitochondria, Rett therapy and oxytocin
These short reports from Spectrum journalists highlight some of the autism-related findings that caught our attention at the meeting this past week.
Reversing mutations in top autism-linked gene makes adult mice more social
Treatments that counteract the effects of an SCN2A mutation in mice increase the animals’ sociability in adulthood, according to a new unpublished study.
Reversing mutations in top autism-linked gene makes adult mice more social
Treatments that counteract the effects of an SCN2A mutation in mice increase the animals’ sociability in adulthood, according to a new unpublished study.
Explore more from The Transmitter
Oxytocin prompts prairie voles to oust outsiders, fortifying their friendships
The “love hormone” drives the neurobiology behind platonic bonds in animals usually studied for their romantic attachments.
Oxytocin prompts prairie voles to oust outsiders, fortifying their friendships
The “love hormone” drives the neurobiology behind platonic bonds in animals usually studied for their romantic attachments.
Contested paper on vaccines, autism in rats retracted by journal
The editor-in-chief cited “inconsistencies in the number of subjects” as the reason for the retraction.
Contested paper on vaccines, autism in rats retracted by journal
The editor-in-chief cited “inconsistencies in the number of subjects” as the reason for the retraction.
Body state, sensory signals commingle in mouse whisker cortex
The new study challenges a long-held view that the barrel cortex exclusively encodes sensory signals from the whiskers.
Body state, sensory signals commingle in mouse whisker cortex
The new study challenges a long-held view that the barrel cortex exclusively encodes sensory signals from the whiskers.