Methods

Recent articles

Photograph of the BRIDGE team and students visiting a laboratory.

Sharing Africa’s brain data: Q&A with Amadi Ihunwo

These data are “virtually mandatory” to advance neuroscience, says Ihunwo, a co-investigator of the Brain Research International Data Governance & Exchange (BRIDGE) initiative, which seeks to develop a global framework for sharing, using and protecting neuroscience data.

By Lauren Schenkman
20 May 2025 | 6 min read
Tic-tac-toe board with pills representing x’s and o’s.

Basic pain research ‘is not working’: Q&A with Steven Prescott and Stéphanie Ratté

Prescott and Ratté critique the clinical relevance of preclinical studies in the field and highlight areas for improvement.

By Sydney Wyatt
18 April 2025 | 7 min read
Research image of olfactory bulb activity.

Smell studies often use unnaturally high odor concentrations, analysis reveals

It’s time to fashion olfactory neuroscience stimuli based on odor concentrations in the wild, say study investigators Elizabeth Hong and Matt Wachowiak.

By Calli McMurray
16 April 2025 | 8 min listen
Research image comparing methods of identifying genes and biological processes linked to Alzheimer's disease.

New tool may help untangle downstream effects of autism-linked genes

The statistical approach helps scientists better control for both measured and unmeasured confounders in gene-expression data, revealing causal relationships between autism-linked genetic variants and downstream cellular effects, such as impaired neuron development.

By Giorgia Guglielmi
27 March 2025 | 5 min read
Data streams into a transparent box.

Accepting “the bitter lesson” and embracing the brain’s complexity

To gain insight into complex neural data, we must move toward a data-driven regime, training large models on vast amounts of information. We asked nine experts on computational neuroscience and neural data analysis to weigh in.

By Eva Dyer, Blake Richards
26 March 2025 | 8 min read
Research image of a fiber optic implant in a mouse brain.

Bespoke photometry system captures variety of dopamine signals in mice

The tool tracks the excitation of an engineered protein that senses dopamine’s absolute levels, including fast and slow fluctuations in real time, and offers new insights into how the signals change across the brain.

By Sydney Wyatt
21 March 2025 | 5 min read
Side view of a Tardigrade.

How tiny tardigrades could help tackle systems neuroscience questions

The eight-legged, millimeter-long animals reveal how small nervous systems produce complex behaviors and perceptual abilities, a preprint suggests.

By Dori Grijseels
11 March 2025 | 6 min read
A geometric figure looks out on an abstract horizon.

The limits of neuroscience

Truly understanding the brain requires a set of conditions we’re unlikely to meet: that knowledge about the brain is finite, and that we have both access to that knowledge and the means to understand it.

By Mark Humphries
10 March 2025 | 8 min read
Two scientists walk along interlocking rings.

Breaking the barrier between theorists and experimentalists

Many neuroscience students are steeped in an experiment-first style of thinking that leads to “random walk science.” Let’s not forget how theory can guide experiments toward deeper insights.

By Samuel Gershman
24 February 2025 | 6 min read
Abstract illustration of overlapping lines.

Claims of necessity and sufficiency are not well suited for the study of complex systems

The earliest studies on necessary and sufficient neural populations were performed on simple invertebrate circuits. Does this logic still serve us as we tackle more sophisticated outputs?

By Grace Lindsay
7 February 2025 | 6 min read

Explore more from The Transmitter

Multisite connectome teams lose federal funding as result of Harvard cuts

The teams aim to develop tools to scale up mouse connectomics in preparation for eventually mapping an entire human brain.

By Angie Voyles Askham
28 May 2025 | 5 min read

Learning in living mice defies classic synaptic plasticity rule

Donald Hebb’s theory—memorably summarized as “cells that fire together, wire together”—does not explain the shifting hippocampal connections in mice learning to navigate a virtual environment, according to a new study.

By Sydney Wyatt
28 May 2025 | 5 min read
Judit Pungor and Angelique Allen stand in front of a saltwater tank.

Cephalopods, vision’s next frontier

For decades, scientists have been teased by the strange but inaccessible cephalopod visual system. Now, thanks to a technological breakthrough from a lab in Oregon, data are finally coming straight from the octopus brain.

By Calli McMurray
27 May 2025 | 13 min read