Systems neuroscience

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Illustration of complex, intersecting biological structures.

Everything, everywhere, all at once: Inside the chaos of Alzheimer’s disease

To truly understand Alzheimer’s disease, we may need to take a systems approach, in which inflammation, vascular injury, impaired glucose metabolism and other factors interact in complex ways.

By Michael A. Yassa
16 June 2025 | 7 min read

Escaping groupthink: What animals’ behavioral quirks reveal about the brain

Neuroscientists have long ignored the variability in animals’ behavioral responses in favor of studying differences across groups. But work on the brain differences that underlie that variability is beginning to pay off.

By Angie Voyles Askham
23 May 2025 | 10 min listen
Research image showing resting-state functional connectivity in the human red nucleus.

‘Ancient’ brainstem structure evolved beyond basic motor control

The human red nucleus may also help coordinate action, reward and motivated behavior, a new study suggests.

By Sydney Wyatt
16 May 2025 | 5 min read
Conceptual illustration of four heads studying representations of neural mechanisms.

This paper changed my life: Marino Pagan recalls a decision-making study from four titans in the field

Valerio Mante and David Sussillo, along with their mentors Krishna Shenoy and Bill Newsome, revealed the complexity of neural population dynamics and the power of recurrent neural networks.

By Marino Pagan
13 May 2025 | 7 min listen
Illustration of a treeline in front of a human brain.

‘Natural Neuroscience: Toward a Systems Neuroscience of Natural Behaviors,’ an excerpt

In his new book, published today, Nachum Ulanovsky calls on the field to embrace naturalistic conditions and move away from overcontrolled experiments.

By Nachum Ulanovsky
15 April 2025 | 9 min read

Explore more from The Transmitter

Astrocytes sense neuromodulators to orchestrate neuronal activity and shape behavior

Astrocytes serve as crucial mediators of neuromodulatory processes previously attributed to direct communication between neurons, four new studies show.

By Claudia López Lloreda
27 June 2025 | 9 min listen

Authors correct image errors in Neuron paper that challenged microglia-to-neuron conversion

The issue with the supplementary figures likely does not change the conclusions of the paper, according to an outside expert.

By Shaena Montanari
26 June 2025 | 3 min read

Building a climate neuroscience subfield: Q&A with Angie Michaiel

Michaiel, a program officer at the Kavli Foundation, shares what it took to cultivate research on the relationship between climate change and the nervous system.

By Calli McMurray
26 June 2025 | 5 min read