Drosophila

Recent articles

A crumpled fly.

Exclusive: Harvard University lays off fly database team

The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades.

By Claudia López Lloreda
13 August 2025 | 5 min listen
Research image of connectomes for two fly species.

Cross-species connectome comparison shows uneven olfactory circuit evolution in flies

The findings start to reveal evolutionary changes that may have helped two species develop different olfactory preferences and adapt to their particular environments.

By Marta Hill
1 August 2025 | 6 min read
Different colored rectangles form the shapes of a bird, fish and insect.

Systems and circuit neuroscience need an evolutionary perspective

To identify fundamental neuroscientific principles that generalize across species, neuroscientists must frame their research through an evolutionary lens.

By Karl Farrow, Katja Reinhard
16 July 2025 | 7 min listen
Illustration of a fly in various poses.

This paper changed my life: Bradley Dickerson on how a 1940s fly neuroanatomy paper influences his research to this day

This classic paper by zoologist John Pringle describes the haltere—a small structure in flies that plays a crucial role in flight control. It taught me to think about circuits and behavior as greater than the sum of their parts.

By Bradley Dickerson
17 June 2025 | 5 min listen
Research image of developing axons in the fly brain.

How developing neurons simplify their search for a synaptic mate

Streamlining the problem from 3D to 1D eases the expedition—a strategy the study investigators deployed to rewire an olfactory circuit in flies.

By Calli McMurray
6 June 2025 | 7 min listen
A crumpled sheet of paper with a fly printed on it.

FlyBase funding squashed amid Harvard grant terminations

The team behind the Drosophila genetics database is now requesting donations from labs to keep the resource afloat.

By Calli McMurray
4 June 2025 | 4 min read
Research image of connectivity in the fly brain.

Connectomics 2.0: Simulating the brain

With a complete fly connectome in hand, researchers are taking the next step to model how brain circuits fuel function.

By Laura Dattaro
2 May 2025 | 11 min read
Multiple people look together at a whiteboard in a lab.

Why practical summer courses in neuroscience matter

Among other reasons, this tradition helps researchers rekindle the unfettered joy that initially brought them to the field.

By John Tuthill
13 January 2025 | 7 min read
Research image of neurons in the fly’s ventral nerve cord.

New connectomes fly beyond the brain

Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.

By Laura Dattaro
26 July 2024 | 7 min read
A dense reconstruction of layer 2/3 neurons of the mouse visual cortex containing 394 neurons and 3.2 million synapses.

To develop better nervous-system visualizations, we need to think BIG

With a full mouse connectome on the horizon, neuroscience needs to overcome its legacy of minimalism and embrace the contemporary challenge of representing whole-nervous-system connectivity.

By Tyler Sloan
8 July 2024 | 8 min read

Explore more from The Transmitter

Research image of neuron organization in c elegans.

Worms help untangle brain structure/function mystery

The synaptic connectome of most animals bears little resemblance to functional brain maps, but it can still predict neuronal activity, according to two preprints that tackle the puzzle in C. elegans

By Holly Barker
29 August 2025 | 7 min read
Research image of microglia in organoids.

Microglia nurture young interneurons

The immune cells secrete a growth factor that “sets the supply of GABAergic interneurons in the developing brain.”

By Lauren Schenkman
28 August 2025 | 4 min read

Xaq Pitkow shares his principles for studying cognition in our imperfect brains and bodies

Pitkow discusses how evolution's messy constraints shape optimal brain algorithms, from Bayesian inference to ecological affordances.

By Paul Middlebrooks
27 August 2025 | 1 min read

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