Optogenetics

Recent articles

Concentric circles.

What are the most transformative neuroscience tools and technologies developed in the past five years?

Artificial intelligence and deep-learning methods featured prominently in the survey responses, followed by genetic tools to control circuits, advanced neuroimaging, transcriptomics and various approaches to record brain activity and behavior.

By The Transmitter
15 November 2025 | 14 min read
Colored outlines form the silhouette of a human brain in profile.

‘How to Change a Memory: One Neuroscientist’s Quest to Alter the Past,’ an excerpt

Part scientific exploration, part memoir, Steve Ramirez’s new book delves into the study of memory manipulation and his personal journey of discovery, friendship and grief.

By Steve Ramirez
7 November 2025 | 9 min read
A worm made of circuitry.

Whole-brain, bottom-up neuroscience: The time for it is now

Applying new tools to entire brains, starting with C. elegans, offers the opportunity to uncover how molecules work together to generate neural physiology and how neurons work together to generate behavior.

By Edward Boyden, Konrad Körding
20 October 2025 | 9 min read

Facial movements telegraph cognition in mice

If you give a mouse a decision, its thought process may show on its face.

By Lauren Schneider
30 September 2025 | 0 min watch
Research image of a mouse brain with the same spot shown three times in different colors to show different neurochemical concentrations.

New dopamine sensor powers three-color imaging in live animals

The tool leverages a previously unused segment of the color spectrum to track the neurotransmitter and can be used with two additional sensors to monitor other neurochemicals at different wavelengths.

By Diana Kwon
25 July 2025 | 4 min read
Research image of red and blue light emitted from the Neuropixels Opto probe.

‘Perturb and record’ optogenetics probe aims precision spotlight at brain structures

The tool provides a new way to characterize cells and study neuronal circuits.

By Claudia López Lloreda
29 April 2025 | 4 min read
Research image of serotonin and dopamine neurons manipulated simultaneously in mice.

Dopamine ‘gas pedal’ and serotonin ‘brake’ team up to accelerate learning

Mice learn fastest and most reliably when they experience an increase in dopamine paired with an inhibition of serotonin in their nucleus accumbens, a new study shows, helping to resolve long-standing questions about the neuromodulators’ relationship.

By Angie Voyles Askham
12 February 2025 | 5 min read
Research image of green and purple mouse brain slices.

Putting a bright idea to the test

A surprising wave of findings in mice suggests that light and sound flickering at 40 hertz clears the brain of Alzheimer’s-disease-linked plaques. Several companies are hoping to prove it works in people.

By Shaena Montanari
21 August 2024 | 11 min read
Portrait of Kaspar Podgorski standing in his lab wearing a helmet with a climbing rope over his shoulder.

Climbing to new heights: Q&A with Kaspar Podgorski

The optical physiologist tracks neural computations inside the lab and scales sheer rock faces outside—even after a life-changing fall.

By Elissa Welle
21 June 2024 | 8 min read

Robots boost data consistency in rodent studies reliant on mechanical, optogenetic stimulation

Two new devices take experimenter variation out of the equation, the lead investigators say.

By Calli McMurray
15 May 2024 | 0 min watch

Explore more from The Transmitter

Among brain changes studied in autism, spotlight shifts to subcortex

The striatum and thalamus are more likely than the cerebral cortex to express autism variants or bear transcriptional changes, two unpublished studies find.

By Holly Barker
11 December 2025 | 5 min read
Brain organoid.

What is the future of organoid and assembloid regulation?

Four experts weigh in on how to establish ethical guardrails for research on the 3D neuron clusters as these models become ever more complex.

By Claudia López Lloreda
10 December 2025 | 7 min read
Research image of variants of the ATPase subunit PSMC5/RPT6.

Insights on suicidality and autism; and more

Here is a roundup of autism-related news and research spotted around the web for the week of 8 December.

By Jill Adams
9 December 2025 | 2 min read

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