Gene networks
Autism-linked proteins mingle with other molecules in overlapping networks
A massive new set of interaction maps illuminates especially high convergence in protein networks related to autism and shows how mutations could disrupt those networks.
Autism-linked proteins mingle with other molecules in overlapping networks
Change of heart and mind: Autism’s ties to cardiac defects
Children with congenital heart disease have an increased likelihood of autism. Why?
Change of heart and mind: Autism’s ties to cardiac defects
Fishing for protein partners nets clues to autism
Connections between 13 autism-linked proteins and their binding partners in excitatory neurons implicate a new molecular pathway.
Fishing for protein partners nets clues to autism
Multi-omics study captures CNTNAP2’s far-ranging effects
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
Multi-omics study captures CNTNAP2’s far-ranging effects
Two top autism-linked proteins connect to build cell ‘skeleton’
ADNP and SHANK3 proteins may bind together and alter a neuron’s internal scaffold, hinting at a mechanism that, when disrupted, may underlie several forms of autism.
Two top autism-linked proteins connect to build cell ‘skeleton’
Autism and the complete human genome: Q&A with Evan Eichler
Scientists have at last filled in the missing gaps — an advance likely to inform every aspect of autism genetics research, Eichler says.
Autism and the complete human genome: Q&A with Evan Eichler
Autism genetics, explained
The more scientists dig into DNA, the more intricate its contribution to autism seems to be. Here, we unravel the complex genetics of autism.
Differing gene functions across species may pose problems for autism models
Misaligned gene expression maps suggest that some autism-linked genes play distinct roles in mouse and human brains.
Differing gene functions across species may pose problems for autism models
Proteome map identifies more than 90 percent of all human proteins
Researchers expand on the already enormous progress made on the Human Proteome Project
Proteome map identifies more than 90 percent of all human proteins
Integrating molecular data may reveal subgroups of autism
An analysis of four molecular datasets shows a distinct signature, including changes in gene expression and chemical DNA modifications, in some autism brains.
Integrating molecular data may reveal subgroups of autism
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Some minimally verbal autistic people show signs of written-language familiarity, study suggests
But researchers not involved in the work worry the findings could be used to support discredited facilitated-communication techniques.
Some minimally verbal autistic people show signs of written-language familiarity, study suggests
But researchers not involved in the work worry the findings could be used to support discredited facilitated-communication techniques.