Neurodegeneration

Recent articles

Research image of cell types in the human brain.

Single-cell genomics technologies and cell atlases have ushered in a new era of human neurobiology

Single-cell approaches are already shedding light on the human brain, identifying cell types that are most vulnerable in the early stages of Alzheimer’s disease, for example.

By Ed Lein, Hongkui Zeng
24 March 2025 | 7 min read
A repeated DNA strand extends farther from the left side of the image with each iteration.

Huntington’s disease gene variants past a certain size poison select cells

The findings—providing “the next step in the whole pathway”—help explain the disease’s late onset and offer hope that it has an extended therapeutic window.

By Angie Voyles Askham
16 January 2025 | 6 min read
Research image of retinal ganglion cells in the lateral geniculate nucleus in mice.

Microglia’s pruning function called into question

Scientists are divided over the extent to which the cells sculpt circuits during development.

By RJ Mackenzie
24 October 2024 | 9 min read
A collage illustration of a woman’s face fragmented by a mosaic of X chromosomes, lines and shapes.

Brains, biases and amyloid beta: Why the female brain deserves a closer look in Alzheimer’s research

New results suggest the disease progresses differently in women, but we need more basic science to unpack the mechanisms involved.

By Rachel Buckley
22 October 2024 | 8 min listen
Research image of tau proteins in the brains of people with Alzheimer’s disease.

Supersized version of Alzheimer’s protein avoids clumping in brain

“Big tau” may explain why some brain regions, such as the cerebellum and brainstem, are largely spared from neurodegeneration, even though tau is expressed throughout the nervous system.

By Charles Q. Choi
16 August 2024 | 6 min read

Explore more from The Transmitter

Abstract illustration of a human brain.

‘Elusive Cures: Why Neuroscience Hasn’t Solved Brain Disorders—and How We Can Change That,’ an excerpt

In her new book, published today, neuroscientist Nicole Rust takes us on her personal quest to spell out the brain research community's "Grand Plan."

By Nicole Rust
10 June 2025 | 9 min read
Illustration of an open journal featuring lines of text and small illustrations of eyes and mouths.

Convergent effects of autism-linked genes in zebrafish; and more

Here is a roundup of autism-related news and research spotted around the web for the week of 9 June.

By Jill Adams
10 June 2025 | 2 min read
Research image containing repeated structures, suggesting potential image manipulation.

More than two dozen papers by neural tube researcher come under scrutiny

One of the studies, published in 2021 in Science Advances, received an editorial expression of concern on 21 May, after the journal learned that an institutional review of alleged image problems is underway.

By Claudia López Lloreda
9 June 2025 | 6 min read