Theories of autism

Recent articles

The signaling imbalance theory of autism, explained

The signaling imbalance theory holds that the brains of autistic people are hyper-excitable because of either excess neuronal activity or weak brakes on that activity.

By Sarah DeWeerdt
1 May 2019 | 4 min read

The female protective effect, explained

One of the leading theories of autism posits that girls and women are biologically protected from the condition.

By Hannah Furfaro
1 May 2019 | 4 min read
Illustration of a strong man holding up a oversized brain

The extreme male brain, explained

The ‘extreme male brain’ theory suggests that autism is an exaggeration of systematic sex differences in ways of thinking.

By Hannah Furfaro
1 May 2019 | 5 min read
Illustration of red figures on a big blue brain are serotonin signaling

Serotonin’s link to autism, explained

Serotonin, the brain chemical best known for its link to depression, may also be involved in autism.

By Nicholette Zeliadt
1 May 2019 | 5 min read
A DNA helix showing common and rare variants

The multiple hits theory of autism, explained

Researchers are studying how a combination of genetic ‘hits’ may contribute to autism’s diversity.

By Jessica Wright
1 May 2019 | 4 min read
Illustration shows the world is distorted through a point of view pair of glasses

The predictive coding theory of autism, explained

In autism, a person's brain may not form accurate predictions of imminent experiences, or even if it does, sensory input may override those predictions.

By George Musser
1 May 2019 | 6 min read
overlapping network of connections in the brain

The connectivity theory of autism, explained

A growing body of evidence suggests that autism involves atypical communication between brain regions, but how and where in the brain this plays out is unclear.

By Rachel Zamzow
1 May 2019 | 4 min read

Explore more from The Transmitter

Mother mouse with pups.

Oxytocin shapes both mouse mom and pup behavior

Distressed pups emit distinct cries for help, which depend on oxytocin neurons in their hypothalamus.

By Claudia López Lloreda
11 September 2025 | 5 min read
Research image showing cell activity in a particular region of the mouse thalamus.

Sensory gatekeeper drives seizures, autism-like behaviors in mouse model

The new work, in mice missing the autism-linked gene CNTNAP2, suggests a mechanism to help explain the overlap between epilepsy and autism.

By Diana Kwon
11 September 2025 | 5 min listen

Michael Breakspear and Mac Shine explain how brain processing changes across neural population scales

Breakspear and Shine find a scale-free property of brain activity that is conserved across diverse species, suggesting that a universal principle of brain activity underlies cognition.

By Paul Middlebrooks
10 September 2025 | 1 min read

privacy consent banner

Privacy Preference

We use cookies to provide you with the best online experience. By clicking “Accept All,” you help us understand how our site is used and enhance its performance. You can change your choice at any time. To learn more, please visit our Privacy Policy.