Cellular neuroscience

Recent articles

Detailed image of neurons in the mouse visual cortex.

Inhibitory cells work in concert to orchestrate neuronal activity in mouse brain

A cubic millimeter of brain tissue, meticulously sectioned, stained and scrutinized over the past seven years, reveals in stunning detail the role of inhibitory interneurons in brain structure and function.

By Katie Moisse
9 April 2025 | 6 min listen
Research image of human cortical neurons xenotransplanted into a mouse brain for months.

In vivo veritas: Xenotransplantation can help us study the development and function of human neurons in a living brain

Transplanted cells offer insight into human-specific properties, such as a lengthy cortical development and sensitivity to neurodevelopmental and neurodegenerative disease.

By Pierre Vanderhaeghen
7 April 2025 | 9 min listen
Research image of an assembloid.

Organoids and assembloids offer a new window into human brain

These sophisticated 3D cultures reveal previously inaccessible stages of human brain development and enable the systematic study of disease genes.

By Sergiu P. Pasca
31 March 2025 | 7 min read
Research image of cell types in the human brain.

Single-cell genomics technologies and cell atlases have ushered in a new era of human neurobiology

Single-cell approaches are already shedding light on the human brain, identifying cell types that are most vulnerable in the early stages of Alzheimer’s disease, for example.

By Ed Lein, Hongkui Zeng
24 March 2025 | 7 min read
Illustration of a pen hovering over a gene sequence-like series of colored rectangles.

This paper changed my life: ‘Histone demethylation mediated by the nuclear amine oxidase homolog LSD1,’ from the Shi Lab

This paper defined key rules of epigenomic regulation and shaped how I study chromatin plasticity as a mechanism for experience-dependent changes in the brain.

By Anne E. West
27 November 2024 | 5 min read
Research image of astrocytes in red activating alongside neurons in green in response to specific fear memories in mice.

Astrocytes star in memory storage, recall

The cells, long cast as support players in memory research, can activate or disrupt fear memories, according to a new study.

By Angie Voyles Askham
6 November 2024 | 5 min read
Collage of different images of brains and mechanical devices in the background with a suitcase in the foreground.

What are mechanisms? Unpacking the term is key to progress in neuroscience

Mechanism is a common and powerful concept, invoked in grant calls and publication guidelines. But scientists use it in different ways, making it difficult to clarify standards in the field. We asked nine scientists to weigh in.

By Dani S. Bassett, Lauren N. Ross
7 October 2024 | 5 min read
Research image of tau proteins in the brains of people with Alzheimer’s disease.

Supersized version of Alzheimer’s protein avoids clumping in brain

“Big tau” may explain why some brain regions, such as the cerebellum and brainstem, are largely spared from neurodegeneration, even though tau is expressed throughout the nervous system.

By Charles Q. Choi
16 August 2024 | 6 min read
Research image of a brain chimera containing neurons from rats and mice.

Is it time to worry about brain chimeras?

Brains made of neurons from two species raise new concerns.

By Joshua R. Sanes
5 August 2024 | 9 min listen

Widely used calcium imaging protocol can lead to spurious results, new paper cautions

The technique, which measures calcium currents as a proxy for neuronal firing, sometimes reports unusual and potentially misleading waves of activity in the hippocampus.

By Angie Voyles Askham
19 June 2024 | 0 min watch

Explore more from The Transmitter

Photograph of the BRIDGE team and students visiting a laboratory.

Sharing Africa’s brain data: Q&A with Amadi Ihunwo

These data are “virtually mandatory” to advance neuroscience, says Ihunwo, a co-investigator of the Brain Research International Data Governance & Exchange (BRIDGE) initiative, which seeks to develop a global framework for sharing, using and protecting neuroscience data.

By Lauren Schenkman
20 May 2025 | 6 min read
Research image of neurite overgrowth in cells grown from people with autism-linked PPP2R5D variants.

Cortical structures in infants linked to future language skills; and more

Here is a roundup of autism-related news and research spotted around the web for the week of 19 May.

By Jill Adams
20 May 2025 | 2 min read
Digitally distorted building blocks.

The BabyLM Challenge: In search of more efficient learning algorithms, researchers look to infants

A competition that trains language models on relatively small datasets of words, closer in size to what a child hears up to age 13, seeks solutions to some of the major challenges of today’s large language models.

By Alona Fyshe
19 May 2025 | 7 min read