Hyperactivity

Recent articles

Illustration of ketamine blocking open ion channels in active NMDA receptors, quieting the cells and disrupting downstream signaling involved in depression.

Ketamine targets lateral habenula, setting off cascade of antidepressant effects

The drug’s affinity for overactive cells in the “anti-reward” region may help explain its rapid and long-lasting results.

By Olivia Gieger
4 September 2024 | 6 min read
A young boy sits alone on a bench in a playground.

Mental health issues emerge with shifts in autism traits across childhood

Anxiety and other challenges autistic children experience may stem from an increase in social-communication issues and a decrease in repetitive behaviors from ages 6 to 11.

By Charles Q. Choi
27 September 2023 | 3 min read
Research image comparing microglia with serotonin receptors to those without.

Serotonin powers pruning of developing brain circuits in mice

Mice with microglia missing receptors for the neurotransmitter serotonin since birth have too many synapses and show social difficulties in adulthood.

By Katie Moisse
28 June 2023 | 5 min listen
Research image of zebrafish forebrains.

Autism-related genes converge on microglia and dopamine in zebrafish

The findings add to the growing evidence that genes with disparate functions can play similar roles in brain development.

By Peter Hess
12 May 2023 | 4 min read
Research image shows elevated expression of certain genes, shown in pink and green, along with expected gene expression, shown in blue.

Autism-linked MYT1L mutations prompt ‘identity crisis’ in budding brain cells

Both human and mouse progenitor cells with the alterations struggle to become neurons and instead express genes that are typically active only in muscle or the heart.

By Laura Dattaro
14 February 2023 | 5 min read
Mouse neurons in red and pink on black.

Mouse model reveals root of breathing issues in rare form of autism

Dysfunctional circuits and a rogue sodium channel in the brainstem may explain the disordered breathing pattern seen in children with Pitt-Hopkins syndrome, a form of autism.

By Anna Goshua
5 November 2021 | 4 min read
Two colorful mouse neurons seen side by side on black, one has a mutation.

Precocious neurons may stunt brain growth in rare form of autism

The first animal model of MYT1L syndrome suggests that fast-maturing neurons lead to the unusually small brains, social deficits and other traits seen in people with the condition.

By Peter Hess
5 October 2021 | 5 min read

Stimulant restores cell signaling, eases behavior issues in animals missing autism gene

Worms and zebrafish missing both copies of the gene CHD7 have disrupted cellular signaling, a dearth of inhibitory neurons and behavior changes — all of which are reversed by the stimulant drug ephedrine.

By Peter Hess
28 May 2021 | 4 min read
Neurons in a macaque cortex express parvalbumin in red.

Virus-based method manipulates inhibitory neurons in brains

A new viral tool can selectively control different types of neurons that dampen brain activity in rodents, monkeys and people.

By Jonathan Moens
9 September 2020 | 4 min read
Young boy biting his fingernails, looking anxiously out the window.

Long-term study tracks persistence of self-harm in autistic people

Autistic people who are hyperactive or have difficulty controlling their own impulses are the most likely to show ongoing self-injury.

By Chloe Williams
21 February 2020 | 4 min read

Explore more from The Transmitter

Research image of EEG scans showing dopamine levels in human brains.

Null and Noteworthy: Learning theory validated 20 years later

The first published paper from the EEGManyLabs replication project nullifies a null result that had complicated a famous reinforcement learning theory.

By Laura Dattaro
30 May 2025 | 4 min read
Gerry Fischbach.

Neuroscientist Gerry Fischbach, in his own words

In 2023, I had the privilege of sitting down with Gerry over the course of several days and listening as he told the story of his life and career—including stints as dean or director of such leading institutions as Columbia University and NINDS—so that we could record it for posterity.

By Ivan Oransky
30 May 2025 | 2 min read
Amina Abubakar, dressed in yellow, stands outside and looks into the camera lens.

Amina Abubakar translates autism research and care for Kenya

First an educator and now an internationally recognized researcher, the Kenyan psychologist is changing autism science and services in sub-Saharan Africa.

By Ruth Kadide Keah
29 May 2025 | 7 min read