Immune system
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
Immune-activation model mice escape infantile amnesia, retain early memories
Male pups born to mothers treated with immune-stimulating molecules show autism-like behaviors and, unlike wildtype animals, do not lose memories formed during early life.
Immune-activation model mice escape infantile amnesia, retain early memories
Male pups born to mothers treated with immune-stimulating molecules show autism-like behaviors and, unlike wildtype animals, do not lose memories formed during early life.
Atlas charts cells of human placenta, uterus across early pregnancy
A new resource gives an unparalleled look at how fetal placental cells attach to the uterine wall and remodel maternal blood vessels to access nutrients.
Atlas charts cells of human placenta, uterus across early pregnancy
A new resource gives an unparalleled look at how fetal placental cells attach to the uterine wall and remodel maternal blood vessels to access nutrients.
‘wildDISCO’ cocktail yields whole-body maps of mouse neurons and more
A new technique used to create see-through rodents can help scientists analyze how the nervous system interacts with other body systems.
‘wildDISCO’ cocktail yields whole-body maps of mouse neurons and more
A new technique used to create see-through rodents can help scientists analyze how the nervous system interacts with other body systems.
Serotonin powers pruning of developing brain circuits in mice
Mice with microglia missing receptors for the neurotransmitter serotonin since birth have too many synapses and show social difficulties in adulthood.
Serotonin powers pruning of developing brain circuits in mice
Mice with microglia missing receptors for the neurotransmitter serotonin since birth have too many synapses and show social difficulties in adulthood.
Maternal immune response dulls male rats’ social radar
Male rats prenatally exposed to a maternal immune response have atypical responses to other rats in distress, according to a new study.
Maternal immune response dulls male rats’ social radar
Male rats prenatally exposed to a maternal immune response have atypical responses to other rats in distress, according to a new study.
Null and Noteworthy: Registered reports; motor measurements; viral DNA
In this edition of Null and Noteworthy, Spectrum talks with a Nature editor about the journal’s move to publish more null results.
Null and Noteworthy: Registered reports; motor measurements; viral DNA
In this edition of Null and Noteworthy, Spectrum talks with a Nature editor about the journal’s move to publish more null results.
Immunity-linked genes expressed differently in brains of autistic people
Postmortem brain samples from people with one of six conditions, including autism, show distinct signatures of over- and underexpression of immune genes.
Immunity-linked genes expressed differently in brains of autistic people
Postmortem brain samples from people with one of six conditions, including autism, show distinct signatures of over- and underexpression of immune genes.
The link between maternal infection and autism, explained
Having an infection during pregnancy is tied to a small increase in the chances of having an autistic child, but the connection may not be causal.
The link between maternal infection and autism, explained
Having an infection during pregnancy is tied to a small increase in the chances of having an autistic child, but the connection may not be causal.
Autism’s sex bias tied to glial, immune cell gene expression
The function of microglia and astrocytes in the brain may mediate the intersection of sex-differential biology and autism biology.
Autism’s sex bias tied to glial, immune cell gene expression
The function of microglia and astrocytes in the brain may mediate the intersection of sex-differential biology and autism biology.
Explore more from The Transmitter
New connectomes fly beyond the brain
Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.
New connectomes fly beyond the brain
Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.
Building an autism research registry: Q&A with Tony Charman
A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.
Building an autism research registry: Q&A with Tony Charman
A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.
Cerebellar circuit may convert expected pain relief into real thing
The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.
Cerebellar circuit may convert expected pain relief into real thing
The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.