Neural coding

Recent articles

A series of colored rectangles in a cosmos-like black space.

The challenge of defining a neural population

Our current approach is largely arbitrary. We need new methods for grouping cells, ideally by their dynamics.

By Mark Humphries
11 August 2025 | 9 min listen

John Beggs unpacks the critical brain hypothesis

Beggs outlines why and how brains operate at criticality, a sweet spot between order and chaos.

By Paul Middlebrooks
21 May 2025 | 94 min listen
Composite image of a brain probe, a test tube and a brain scan.

Why the 21st-century neuroscientist needs to be neuroethically engaged

Technological advances in decoding brain activity and in growing human brain cells raise new ethical issues. Here is a framework to help researchers navigate them.

By Karen Rommelfanger
12 May 2025 | 6 min read
Mock-up of the Neuropixels probe inserted into brain tissue.

Tracking single neurons in the human brain reveals new insight into language and other human-specific functions

Better technologies to stably monitor cell populations over long periods of time make it possible to study neural coding and dynamics in the human brain.

By Edward Chang, Jason Chung
28 April 2025 | 7 min read

It’s time to examine neural coding from the message’s point of view

In studying the brain, we almost always take the neuron’s perspective. But we can gain new insights by reorienting our frame of reference to that of the messages flowing over brain networks.

By Daniel Graham
1 April 2025 | 0 min watch

Dmitri Chklovskii outlines how single neurons may act as their own optimal feedback controllers

From logical gates to grandmother cells, neuroscientists have employed many metaphors to explain single neuron function. Chklovskii makes the case that neurons are actually trying to control how their outputs affect the rest of the brain.

By Paul Middlebrooks
12 February 2025 | 99 min listen
Multicolored illustration of a human brain as seen from the top down.

Most neurons in mouse cortex defy functional categories

The majority of cells in the cerebral cortex are unspecialized, according to an unpublished analysis—and scientists need to take care in naming neurons, the researchers warn.

By Holly Barker
7 January 2025 | 5 min read

Eli Sennesh talks about bridging predictive coding and NeuroAI

Predictive coding is an enticing theory of brain function. Building on decades of models and experimental work, Eli Sennesh proposes a biologically plausible way our brain might implement it.

By Paul Middlebrooks
3 January 2025 | 98 min listen
Illustration of distorted lines of different colors being pulled into a box where they are smoothed in a single multicolored line.

The Transmitter’s favorite essays and columns of 2024

From sex differences in Alzheimer’s disease to enduring citation bias, experts weighed in on important scientific and practical issues in neuroscience.

By The Transmitter
23 December 2024 | 2 min read

Rajesh Rao reflects on predictive brains, neural interfaces and the future of human intelligence

Twenty-five years ago, Rajesh Rao proposed a seminal theory of how brains could implement predictive coding for perception. His modern version zeroes in on actions.

By Paul Middlebrooks
18 December 2024 | 97 min listen

Explore more from The Transmitter

Exclusive: Who is Richard Frye, the neurologist who researches and advocates for leucovorin as an autism treatment?

Frye has led two placebo-controlled trials of the folate supplement in autistic people; the first was suspended by regulators, and the other has yet to be published.

By Brendan Borrell
1 October 2025 | 11 min read
Illustration of a brain surrounded by a stylized silhouette of a human head with psychedelic colors and textures.

Why we need basic science to better understand the neurobiology of psychedelics

Despite the many psychedelics clinical trials underway, there is still much we don’t know about how these drugs work. Preclinical studies represent our best viable avenue to answer these lingering questions.

By Devin Effinger, Melissa Herman
1 October 2025 | 7 min listen

Facial movements telegraph cognition in mice

If you give a mouse a decision, its thought process may show on its face.

By Lauren Schneider
30 September 2025 | 0 min watch

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