Timothy syndrome
Recent articles
Organoids and assembloids offer a new window into human brain
These sophisticated 3D cultures reveal previously inaccessible stages of human brain development and enable the systematic study of disease genes.
Organoids and assembloids offer a new window into human brain
These sophisticated 3D cultures reveal previously inaccessible stages of human brain development and enable the systematic study of disease genes.
RNA drug corrects calcium signaling in chimeric model of Timothy syndrome
The drug, tested in rats that have human neurons, could enter clinical testing as early as next year, researchers say.
RNA drug corrects calcium signaling in chimeric model of Timothy syndrome
The drug, tested in rats that have human neurons, could enter clinical testing as early as next year, researchers say.
Human cortical organoids forge functional circuits in rat brains
The transplanted cells integrate into living animals’ neural circuitry and influence behavior.
Human cortical organoids forge functional circuits in rat brains
The transplanted cells integrate into living animals’ neural circuitry and influence behavior.
Mini-brains bare tortuous trek of cells in Timothy syndrome
A new technique for building a ‘brain in a dish’ reveals how neurons move to their proper places during fetal development.
Mini-brains bare tortuous trek of cells in Timothy syndrome
A new technique for building a ‘brain in a dish’ reveals how neurons move to their proper places during fetal development.
Mighty element plays major part in autism
Probing the function of a protein in a calcium signaling pathway may lead to a diagnostic test for autism and a path toward treatments.
Mighty element plays major part in autism
Probing the function of a protein in a calcium signaling pathway may lead to a diagnostic test for autism and a path toward treatments.
Rising Star: Sergiu Pasca, scientist at play
Sergiu Pasca was among the first to model autism with neurons from affected individuals, a feat that could reveal the biochemical roots of some forms of autism.
Rising Star: Sergiu Pasca, scientist at play
Sergiu Pasca was among the first to model autism with neurons from affected individuals, a feat that could reveal the biochemical roots of some forms of autism.
Rho family of enzymes at crossroads of autism
A number of autism risk factors converge on one cellular pathway: abnormal remodeling of the cell's structural systems through the signaling protein Rho, says SFARI’s associate director for research, Alan Packer.
Rho family of enzymes at crossroads of autism
A number of autism risk factors converge on one cellular pathway: abnormal remodeling of the cell's structural systems through the signaling protein Rho, says SFARI’s associate director for research, Alan Packer.
Molecular mechanisms: Timothy syndrome neurons defective
Neurons from people with Timothy syndrome, and from mouse and rat models of the disorder, have defects in the growth of their branches, according to a study published 13 January in Nature Neuroscience.
Molecular mechanisms: Timothy syndrome neurons defective
Neurons from people with Timothy syndrome, and from mouse and rat models of the disorder, have defects in the growth of their branches, according to a study published 13 January in Nature Neuroscience.
Exploring enigmatic links between mitochondria and autism
Mitochondrial deficits may account for the range of symptoms and neurological deficits seen in autism and explain why it preferentially affects boys, says Douglas Wallace.
Exploring enigmatic links between mitochondria and autism
Mitochondrial deficits may account for the range of symptoms and neurological deficits seen in autism and explain why it preferentially affects boys, says Douglas Wallace.
Allen Institute aims to mass-produce stem cells
The nonprofit Allen Institute for Brain Science in Seattle plans to make neurons from stem cells derived from people with a number of different disorders. The resource, described 25 September at a conference in New York, will be available to all scientists.
Allen Institute aims to mass-produce stem cells
The nonprofit Allen Institute for Brain Science in Seattle plans to make neurons from stem cells derived from people with a number of different disorders. The resource, described 25 September at a conference in New York, will be available to all scientists.
Explore more from The Transmitter
More than two dozen papers by neural tube researcher come under scrutiny
One of the studies, published in 2021 in Science Advances, received an editorial expression of concern on 21 May, after the journal learned that an institutional review of alleged image problems is underway.
More than two dozen papers by neural tube researcher come under scrutiny
One of the studies, published in 2021 in Science Advances, received an editorial expression of concern on 21 May, after the journal learned that an institutional review of alleged image problems is underway.
On the importance of reading (just not too much)
The real fun of being a neuroscientist, and maybe the key to asking and answering new questions, is to think big and take intellectual risks.
On the importance of reading (just not too much)
The real fun of being a neuroscientist, and maybe the key to asking and answering new questions, is to think big and take intellectual risks.
How developing neurons simplify their search for a synaptic mate
Streamlining the problem from 3D to 1D eases the expedition—a strategy the study investigators deployed to rewire an olfactory circuit in flies.
How developing neurons simplify their search for a synaptic mate
Streamlining the problem from 3D to 1D eases the expedition—a strategy the study investigators deployed to rewire an olfactory circuit in flies.