Methods

Recent articles

A series of colored rectangles in a cosmos-like black space.

The challenge of defining a neural population

Our current approach is largely arbitrary. We need new methods for grouping cells, ideally by their dynamics.

By Mark Humphries
11 August 2025 | 9 min listen
Artistic illustration of a neural manifold.

Neural population-based approaches have opened new windows into neural computations and behavior

Neural manifold properties can help us understand how animal brains deal with complex information, execute flexible behaviors and reuse common computations.

By Matthew Perich
4 August 2025 | 8 min listen
Research image of a mouse brain with the same spot shown three times in different colors to show different neurochemical concentrations.

New dopamine sensor powers three-color imaging in live animals

The tool leverages a previously unused segment of the color spectrum to track the neurotransmitter and can be used with two additional sensors to monitor other neurochemicals at different wavelengths.

By Diana Kwon
25 July 2025 | 5 min listen
A crumpled sheet of paper with a fly printed on it.

FlyBase funding squashed amid Harvard grant terminations

The team behind the Drosophila genetics database is now requesting donations from labs to keep the resource afloat.

By Calli McMurray
4 June 2025 | 4 min read
Illustration of a brain with a window opening into it.

To understand the brain as a network organ, we must image cortical layers

Human neuroscience research has largely overlooked this spatial scale—which bridges cells and brain areas. But new advances in functional MRI technology are changing that.

By Laurentius Huber
2 June 2025 | 7 min listen
Photograph of the BRIDGE team and students visiting a laboratory.

Sharing Africa’s brain data: Q&A with Amadi Ihunwo

These data are “virtually mandatory” to advance neuroscience, says Ihunwo, a co-investigator of the Brain Research International Data Governance & Exchange (BRIDGE) initiative, which seeks to develop a global framework for sharing, using and protecting neuroscience data.

By Lauren Schenkman
20 May 2025 | 6 min read
Tic-tac-toe board with pills representing x’s and o’s.

Basic pain research ‘is not working’: Q&A with Steven Prescott and Stéphanie Ratté

Prescott and Ratté critique the clinical relevance of preclinical studies in the field and highlight areas for improvement.

By Sydney Wyatt
18 April 2025 | 7 min read
Research image of olfactory bulb activity.

Smell studies often use unnaturally high odor concentrations, analysis reveals

It’s time to fashion olfactory neuroscience stimuli based on odor concentrations in the wild, say study investigators Elizabeth Hong and Matt Wachowiak.

By Calli McMurray
16 April 2025 | 8 min listen
Research image comparing methods of identifying genes and biological processes linked to Alzheimer's disease.

New tool may help untangle downstream effects of autism-linked genes

The statistical approach helps scientists better control for both measured and unmeasured confounders in gene-expression data, revealing causal relationships between autism-linked genetic variants and downstream cellular effects, such as impaired neuron development.

By Giorgia Guglielmi
27 March 2025 | 5 min read
Data streams into a transparent box.

Accepting “the bitter lesson” and embracing the brain’s complexity

To gain insight into complex neural data, we must move toward a data-driven regime, training large models on vast amounts of information. We asked nine experts on computational neuroscience and neural data analysis to weigh in.

By Eva Dyer, Blake Richards
26 March 2025 | 8 min read

Explore more from The Transmitter

Illustration of a musical staff with notes represented by neurons.

This paper changed my life: Abigail Person on birdsong, feed-forward circuits and convergent computations

By isolating specific neuron types involved in zebra finch birdsong, this 2002 Nature paper from Michael Fee and colleagues revealed elegant neural mechanisms controlling the timing of natural learned behavior.

By Abigail Person
12 August 2025 | 6 min listen
Research image of mouse auditory brainstems.

Prosocial effects of oxytocin are state dependent; and more

Here is a roundup of autism-related news and research spotted around the web for the week of 11 August.

By Jill Adams
12 August 2025 | 2 min read
Two prairie voles.

Oxytocin prompts prairie voles to oust outsiders, fortifying their friendships

The “love hormone” drives the neurobiology behind platonic bonds in animals usually studied for their romantic attachments.

By Holly Barker
8 August 2025 | 8 min listen