Ion channels

Recent articles

Annette Dolphin.

Remembering Annette Dolphin, who helped explain gabapentin’s effects

The "intuitive" neuropharmacologist pushed against the status quo.

By Michael Eisenstein
13 March 2026 | 7 min read
Stack of papers.

What are the most-cited neuroscience papers from the past 30 years?

Highly cited papers reflect the surge in artificial-intelligence research in the field and other technical advances, plus prizewinning work on analgesics, the fusiform face area and ion channels.

By The Transmitter
15 November 2025 | 11 min read
Illustration of ketamine blocking open ion channels in active NMDA receptors, quieting the cells and disrupting downstream signaling involved in depression.

Ketamine targets lateral habenula, setting off cascade of antidepressant effects

The drug’s affinity for overactive cells in the “anti-reward” region may help explain its rapid and long-lasting results.

By Olivia Gieger
4 September 2024 | 6 min read
Photograph of Theanne Griffith sitting at a table with her hands interlocked over a stack of books, with one that she has published at the very top.

Crafting tales of science with Theanne Griffith

A lifelong passion for writing helped the neuroscientist land a book deal and publish 15 chapter books for early readers, covering topics ranging from what the cerebellum does to how a cake bakes.

By Angie Voyles Askham
26 August 2024 | 8 min read
Research image of two fluorescent-stained organoids.

CRISPR gives autism-linked genes a boost, rescues functioning

A modified form of the gene-editing tool increases the expression of CHD8 and SCN2A, showing potential for autism therapies.

By Giorgia Guglielmi
23 May 2024 | 5 min read
Research image of microglia in mice.

Microglial overreaction to atypical neurons may drive autism

In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.

By Holly Barker
21 March 2024 | 5 min read
Black-and-white photograph of William Catterall in a lab.

The legacy of William Catterall, ‘father of ion channels’

Catterall, who characterized the structure, function and regulation of sodium and calcium channels crucial for neuronal excitability, died last month at the age of 77.

By Calli McMurray
12 March 2024 | 7 min read
A research image of neuronal dendrites in mice.

Top autism-linked genes join forces to shape synaptic plasticity

The protein products of ANK2 and SCN2A interact to regulate dendritic excitability.

By Holly Barker
29 January 2024 | 4 min read
Figure shows cultured human kidney cells and cultured rat cortical neurons responding to light exposure.

Unconventional optogenetics technique spurs long-lasting changes in neuronal activity

Conventional optogenetic manipulations to excite or inhibit neurons stop when the light switches off. A new approach makes the changes last.

By Peter Hess
9 January 2023 | 4 min read
Laura Cancedda in Iama's lab.

Building a better drug

Iama Therapeutics is hoping a new class of molecule will prove successful against an old target in autism.

By Alla Katsnelson
6 October 2022 | 12 min read

Explore more from The Transmitter

Outside influences on CHD8 variant phenotypes, and more

Here is a roundup of autism-related news and research spotted around the web for the week of 18 May.

By Jill Adams
19 May 2026 | 2 min read
stack of books illustration.

Reforming neuroscience graduate education for—and with—AI

In disrupting the status quo, artificial intelligence can help us critically reassess and redefine what neuroscience graduate training should look like—and potentially address long-standing training challenges in novel and innovative ways.

By Tari Tan
19 May 2026 | 7 min read
deciphering emotion illustration.

What can AI teach us about ‘emotions’?

Exploring why Anthropic’s AI, Claude, displays something like emotion could ultimately help us better understand the function that emotions serve in humans.

By Nicole Rust
18 May 2026 | 7 min read