Manifolds

Recent articles

Tatiana Engel explains how to connect high-dimensional neural circuitry with low-dimensional cognitive functions

Neuroscientists have long sought to understand the relationship between structure and function in the vast connectivity and activity patterns in the brain. Engel discusses her modeling approach to discovering the hidden patterns that connect the two.

By Paul Middlebrooks
3 December 2025 | 1 min read
Illustration of a colorful, donut-shaped object resting on a distorted plane with its own topography.

Neural manifolds: Latest buzzword or pathway to understand the brain?

When you cut away the misconceptions, neural manifolds present a conceptually appropriate level at which systems neuroscientists can study the brain.

By Matthew Perich
2 October 2024 | 8 min read

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Connexiohuman Connexin 26 dodecamer at 90mmHg PCO2, pH7.4

Designer synapses edit brain circuits in living animals

The approach could help elucidate relationships between circuit structure and function, as well as the role of natural electrical synapses.

By Simon Makin
23 June 2026 | 5 min read
Research image of cortical excitation–inhibition balance.

Role of GABA-A receptors in dup15q syndrome, and more

Here is a roundup of autism-related news and research spotted around the web for the week of 22 June.

By Jill Adams
23 June 2026 | 2 min read
Thermal image of Danionella fish.

Exclusive: Janelia sunsets rodent work, launches transparent fish project

The Howard Hughes Medical Institute’s Janelia Research Campus is banking on whole-brain imaging in the Danionella fish to advance neuroscience, but some scientists forced to close their labs say that even with a three-year runway and transitional support, they feel betrayed by the pivot.

By Calli McMurray
22 June 2026 | 5 min read