Single-cell sequencing
Autism-linked perturbations converge on cell skeleton and RNA-binding proteins
The findings solidify the idea that autism-linked mutations affect brain activity by way of several key shared mechanisms.
Autism-linked perturbations converge on cell skeleton and RNA-binding proteins
Vast diversity of human brain cell types revealed in trove of new datasets
The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.
Vast diversity of human brain cell types revealed in trove of new datasets
Multi-omics study captures CNTNAP2’s far-ranging effects
The in-depth approach shows mutations in the autism-linked gene disrupt neuronal growth and communication, as well as mitochondrial gene expression.
Multi-omics study captures CNTNAP2’s far-ranging effects
Autism brain signature most pronounced in sensory areas
An analysis of 11 cortical regions shows anterior-to-posterior shifts in gene expression linked to autism.
Autism brain signature most pronounced in sensory areas
Glial cells star in autism-linked gene expression analysis
Many genes linked to autism are switched on in the brain's glia, cells that help neurons develop and synapses form.
Glial cells star in autism-linked gene expression analysis
New tool maps cell types in lab-grown blobs of brain tissue
The software compares gene expression in cells derived from organoids with a reference atlas of the developing mouse brain.
New tool maps cell types in lab-grown blobs of brain tissue
Intact-cell sequencing lays bare new view of genome structure
The technique enables researchers to sequence the DNA of an intact cell, providing a unique view of the genome’s organization inside the nucleus.
Intact-cell sequencing lays bare new view of genome structure
Atlas maps distinct cell types during earliest stages of brain development
A new atlas profiles gene activity early on during development in the human fetal brain.
Atlas maps distinct cell types during earliest stages of brain development
Brain activity jump-starts autism-linked genes in human neurons
Some neurons activate autism-linked genes when they fire, according to a new study.
Brain activity jump-starts autism-linked genes in human neurons
Atlas pair profiles fetal gene expression, regulation in single cells
A pair of new atlases that profile millions of cells across 15 organs offer an unparalleled look at gene activity during fetal development.
Atlas pair profiles fetal gene expression, regulation in single cells
Explore more from The Transmitter
Some minimally verbal autistic people show signs of written-language familiarity, study suggests
But researchers not involved in the work worry the findings could be used to support discredited facilitated-communication techniques.
Some minimally verbal autistic people show signs of written-language familiarity, study suggests
But researchers not involved in the work worry the findings could be used to support discredited facilitated-communication techniques.
Cocaine, morphine commandeer neurons normally activated by food, water in mice
Confirming a long-held hypothesis, repeated exposure to the drugs alters neurons in the nucleus accumbens, the brain’s reward center, and curbs an animal’s urge for sustenance.
Cocaine, morphine commandeer neurons normally activated by food, water in mice
Confirming a long-held hypothesis, repeated exposure to the drugs alters neurons in the nucleus accumbens, the brain’s reward center, and curbs an animal’s urge for sustenance.
X chromosome inactivation; motor difficulties in 16p11.2 duplication and deletion; oligodendroglia
Here is a roundup of autism-related news and research spotted around the web for the week of 6 May.
X chromosome inactivation; motor difficulties in 16p11.2 duplication and deletion; oligodendroglia
Here is a roundup of autism-related news and research spotted around the web for the week of 6 May.