Electrophysiology

Recent articles

Research image of red and blue light emitted from the Neuropixels Opto probe.

‘Perturb and record’ optogenetics probe aims precision spotlight at brain structures

The tool provides a new way to characterize cells and study neuronal circuits.

By Claudia López Lloreda
29 April 2025 | 4 min read
Mock-up of the Neuropixels probe inserted into brain tissue.

Tracking single neurons in the human brain reveals new insight into language and other human-specific functions

Better technologies to stably monitor cell populations over long periods of time make it possible to study neural coding and dynamics in the human brain.

By Edward Chang, Jason Chung
28 April 2025 | 7 min read
Patient being administered an EEG test.

Single-neuron recordings are helping to unravel complexities of human cognition

As this work begins to bear fruit, researchers “are becoming less afraid to ask very difficult questions that you can uniquely ask in people.”

By Claudia López Lloreda
14 March 2025 | 10 min listen
Illustration of a mouse melting in front of a fan.

To beat the heat, hypothalamus neurons in mice ramp up their firing

The uptick may help the rodents acclimate to temperature hikes and keep their cool.

By Calli McMurray
11 December 2024 | 7 min read
Illustration of a funnel taking abstract shapes in at the top and spouting an organized flow of shapes out at the bottom.

To keep or not to keep: Neurophysiology’s data dilemma

An exponential growth in data size presents neuroscientists with a significant challenge: Should we be keeping all raw data or focusing on processed datasets? I asked experimentalists and theorists for their thoughts.

By Nima Dehghani
25 November 2024 | 5 min read
Three rhesus macaque monkeys.

Monkeys’ amygdala cells adapt to social status

The cells’ activity reflects social hierarchies and may enable flexible behavior.

By Angie Voyles Askham
6 November 2024 | 4 min read
Research image of neuron positions over time in mouse brain recordings.

Electrical fingerprints track single neurons over several months

The new approach, called UnitMatch, improves on past methods for analyzing large electrophysiological datasets, the researchers say.

By Claudia López Lloreda
1 November 2024 | 6 min read
Research image of mouse brain scans.

Widely distributed brain areas sync to orchestrate decisions in rodents

Multiple brain areas synchronize their activity to help a rodent accumulate the evidence it needs to make a choice, two new studies suggest.

By Claudia López Lloreda
29 October 2024 | 7 min read
Illustration of distorted lines of different colors being pulled into a box where they are smoothed in a single multicolored line.

Averaging is a convenient fiction of neuroscience

But neurons don’t take averages. This ubiquitous practice hides from us how the brain really works.

By Mark Humphries
23 September 2024 | 7 min read
Illustration of cranes attempting to assemble a structure out of very small black squares.

Reconstructing dopamine’s link to reward

The field is grappling with whether to modify the long-standing theory of reward prediction error—or abandon it entirely.

By Angie Voyles Askham
13 September 2024 | 20 min listen

Explore more from The Transmitter

Photograph of the BRIDGE team and students visiting a laboratory.

Sharing Africa’s brain data: Q&A with Amadi Ihunwo

These data are “virtually mandatory” to advance neuroscience, says Ihunwo, a co-investigator of the Brain Research International Data Governance & Exchange (BRIDGE) initiative, which seeks to develop a global framework for sharing, using and protecting neuroscience data.

By Lauren Schenkman
20 May 2025 | 6 min read
Research image of neurite overgrowth in cells grown from people with autism-linked PPP2R5D variants.

Cortical structures in infants linked to future language skills; and more

Here is a roundup of autism-related news and research spotted around the web for the week of 19 May.

By Jill Adams
20 May 2025 | 2 min read
Digitally distorted building blocks.

The BabyLM Challenge: In search of more efficient learning algorithms, researchers look to infants

A competition that trains language models on relatively small datasets of words, closer in size to what a child hears up to age 13, seeks solutions to some of the major challenges of today’s large language models.

By Alona Fyshe
19 May 2025 | 7 min read