Electrophysiology
Recent articles
Remembering A. James Hudspeth, hair cell explorer
Hudspeth, who died 16 August at age 79, devoted his 50-year career to untangling how the ear converts sound into electrical signals.

Remembering A. James Hudspeth, hair cell explorer
Hudspeth, who died 16 August at age 79, devoted his 50-year career to untangling how the ear converts sound into electrical signals.
‘Perturb and record’ optogenetics probe aims precision spotlight at brain structures
The tool provides a new way to characterize cells and study neuronal circuits.

‘Perturb and record’ optogenetics probe aims precision spotlight at brain structures
The tool provides a new way to characterize cells and study neuronal circuits.
Tracking single neurons in the human brain reveals new insight into language and other human-specific functions
Better technologies to stably monitor cell populations over long periods of time make it possible to study neural coding and dynamics in the human brain.

Tracking single neurons in the human brain reveals new insight into language and other human-specific functions
Better technologies to stably monitor cell populations over long periods of time make it possible to study neural coding and dynamics in the human brain.
Single-neuron recordings are helping to unravel complexities of human cognition
As this work begins to bear fruit, researchers “are becoming less afraid to ask very difficult questions that you can uniquely ask in people.”

Single-neuron recordings are helping to unravel complexities of human cognition
As this work begins to bear fruit, researchers “are becoming less afraid to ask very difficult questions that you can uniquely ask in people.”
To beat the heat, hypothalamus neurons in mice ramp up their firing
The uptick may help the rodents acclimate to temperature hikes and keep their cool.

To beat the heat, hypothalamus neurons in mice ramp up their firing
The uptick may help the rodents acclimate to temperature hikes and keep their cool.
To keep or not to keep: Neurophysiology’s data dilemma
An exponential growth in data size presents neuroscientists with a significant challenge: Should we be keeping all raw data or focusing on processed datasets? I asked experimentalists and theorists for their thoughts.

To keep or not to keep: Neurophysiology’s data dilemma
An exponential growth in data size presents neuroscientists with a significant challenge: Should we be keeping all raw data or focusing on processed datasets? I asked experimentalists and theorists for their thoughts.
Monkeys’ amygdala cells adapt to social status
The cells’ activity reflects social hierarchies and may enable flexible behavior.

Monkeys’ amygdala cells adapt to social status
The cells’ activity reflects social hierarchies and may enable flexible behavior.
Electrical fingerprints track single neurons over several months
The new approach, called UnitMatch, improves on past methods for analyzing large electrophysiological datasets, the researchers say.

Electrical fingerprints track single neurons over several months
The new approach, called UnitMatch, improves on past methods for analyzing large electrophysiological datasets, the researchers say.
Widely distributed brain areas sync to orchestrate decisions in rodents
Multiple brain areas synchronize their activity to help a rodent accumulate the evidence it needs to make a choice, two new studies suggest.

Widely distributed brain areas sync to orchestrate decisions in rodents
Multiple brain areas synchronize their activity to help a rodent accumulate the evidence it needs to make a choice, two new studies suggest.
Averaging is a convenient fiction of neuroscience
But neurons don’t take averages. This ubiquitous practice hides from us how the brain really works.

Averaging is a convenient fiction of neuroscience
But neurons don’t take averages. This ubiquitous practice hides from us how the brain really works.
Explore more from The Transmitter
Worms help untangle brain structure/function mystery
The synaptic connectome of most animals bears little resemblance to functional brain maps, but it can still predict neuronal activity, according to two preprints that tackle the puzzle in C. elegans.

Worms help untangle brain structure/function mystery
The synaptic connectome of most animals bears little resemblance to functional brain maps, but it can still predict neuronal activity, according to two preprints that tackle the puzzle in C. elegans.
Microglia nurture young interneurons
The immune cells secrete a growth factor that “sets the supply of GABAergic interneurons in the developing brain.”

Microglia nurture young interneurons
The immune cells secrete a growth factor that “sets the supply of GABAergic interneurons in the developing brain.”
Xaq Pitkow shares his principles for studying cognition in our imperfect brains and bodies
Pitkow discusses how evolution's messy constraints shape optimal brain algorithms, from Bayesian inference to ecological affordances.
Xaq Pitkow shares his principles for studying cognition in our imperfect brains and bodies
Pitkow discusses how evolution's messy constraints shape optimal brain algorithms, from Bayesian inference to ecological affordances.