Altered translation in SYNGAP1-deficient mice; and more

Molecular ministrations: Deficits in synaptic plasticity observed in mice missing one copy of the gene SYNGAP1 are linked to altered translation of specific mRNA species, according to a new study. The changes, particularly in longer transcripts that influence synaptic regulation, cause deficits in synaptic plasticity in hippocampal neurons and appear to mimic changes seen in long-term potentiation. These alterations differ from those observed in a mouse model of fragile X syndrome, another condition linked to autism and intellectual disability. eNeuro
See also: “SYNGAP1 findings illuminate links between mutations, intellectual disability”

More autism research we spotted:

• “Expansion of the genotypic and phenotypic spectrum of SETD5 disorder using data from the national brain gene registry” Clinical Genetics
• “Trends in mental health diagnoses among publicly insured children” JAMA
• “Evaluating canonical babbling ratios extracted from day-long audio recordings in infants later diagnosed with autism spectrum disorder” Infant Behavior and Development
• “Functional connectivity between the visual and salience networks and autistic social features at school-age” Journal of Neurodevelopmental Disorders
• “The intersection of variability in gross motor performance and adaptive behavior in young autistic children: Combining video data analysis and standardized assessments” Autism Research
  See also: “A new look at walking in early childhood: Q&A with Rujuta Wilson”