Psychedelics

Recent articles

Hands cut a ribbon.

What Trump’s psychedelics executive order means for basic neuroscience

The order provides a potential path to remove some psychedelic drugs from the strictest regulatory category, yet it “may not be the breakthrough the basic research community has been looking for,” says neuroscientist Shawn Lockery.

By Calli McMurray
24 April 2026 | 4 min read
A mouse stands on a gloved hand.

Psychedelics research in rodents has a behavior problem

Simple behavioral assays—originally validated as drug-screening tools—fall short in studies that aim to unpack the psychedelic mechanism of action, so some behavioral neuroscientists are developing more nuanced tasks.

By Calli McMurray
19 December 2025 | 8 min read

Psilocybin rewires specific mouse cortical networks in lasting ways

Neuronal activity induced by the psychedelic drug strengthens inputs from sensory brain areas and weakens cortico-cortical recurrent loops.

By Siddhant Pusdekar
5 December 2025 | 0 min watch
A man with glasses reads from a paper with a graph-like pattern of peaks and valleys on it.

The buzziest neuroscience papers of 2023, 2024

The field took note of work on brain-computer interfaces for speech, the mechanism of psychedelics, a broader definition of hippocampal representations, and more.

By Calli McMurray, Francisco J. Rivera Rosario
15 November 2025 | 18 min read
Research image of altered neurovascular coupling after exposure to psychedelics.

Psychedelics muddy fMRI results: Q&A with Adam Bauer and Jonah Padawer-Curry

The drugs disrupt the link between vascular and neuronal activity, which complicates interpretations of fMRI data. Adopting a more holistic view of what constitutes brain activity may help, the researchers say.

By Calli McMurray
29 October 2025 | 7 min read
Illustration of a brain surrounded by a stylized silhouette of a human head with psychedelic colors and textures.

Why we need basic science to better understand the neurobiology of psychedelics

Despite the many psychedelics clinical trials underway, there is still much we don’t know about how these drugs work. Preclinical studies represent our best viable avenue to answer these lingering questions.

By Devin Effinger, Melissa Herman
1 October 2025 | 6 min read
Crumpled pieces of paper form an X.

Psychedelics meta-analysis retracted after authors request ‘significant changes’

While working on a similar analysis last year, an independent researcher spotted inconsistencies in the now-retracted paper.

By Marta Hill
11 June 2025 | 2 min read

Explore more from The Transmitter

Research image of inputs into a single neuron in the mouse visual cortex.

‘Unbelievably beautiful’ evidence extends Nobel Prize-winning model of vision

Orientation tuning—the ability to distinguish a horizontal line from a vertical one or something in between—originates in the visual cortex, according to new mouse synapse imaging experiments.

By Claudia López Lloreda
29 May 2026 | 5 min read
Illustration of people connecting basic science.

Bringing basic biology back to INSAR

As the International Society for Autism Research has grown over the past two decades, basic science has become less central, Christine Wu Nordahl says. This year, she and other meeting organizers aimed to change that.

By Diana Kwon
28 May 2026 | 6 min read
Illustration of scale balancing Petri dish and test tubes.

Every neuroscience lab needs an ethicist

The ethics issues that arise in neuroscience research are usually novel, unresolved and understudied. Embedding ethicists in labs helps scientists navigate these challenges and develop strategies in real time to prevent harm.

By Timothy E. Brown
27 May 2026 | 5 min read