SHANK3
Recent articles
Advances in genetic medicine took center stage at INSAR
The president of the Autism Science Foundation and parent of a child with profound autism reflects on how advances in the treatment of rare gene variants bring hope to many families.
Advances in genetic medicine took center stage at INSAR
The president of the Autism Science Foundation and parent of a child with profound autism reflects on how advances in the treatment of rare gene variants bring hope to many families.
Autism-linked perturbations converge on cell skeleton and RNA-binding proteins
The findings solidify the idea that autism-linked mutations affect brain activity by way of several key shared mechanisms.
Autism-linked perturbations converge on cell skeleton and RNA-binding proteins
The findings solidify the idea that autism-linked mutations affect brain activity by way of several key shared mechanisms.
New test taps nose pokes as a proxy for social motivation in mice
Over one hour, a particularly motivated mouse poked its nose 350 times into a hole in the test chamber in the hopes of meeting a playmate.
New test taps nose pokes as a proxy for social motivation in mice
Over one hour, a particularly motivated mouse poked its nose 350 times into a hole in the test chamber in the hopes of meeting a playmate.
Autism’s ties to the cell skeleton
Many genes related to the condition play a role in the internal scaffolding of cells, and cytoskeletal disruptions can affect neurodevelopment and behavior.
Autism’s ties to the cell skeleton
Many genes related to the condition play a role in the internal scaffolding of cells, and cytoskeletal disruptions can affect neurodevelopment and behavior.
On the periphery: Thinking ‘outside the brain’ offers new ideas about autism
Neuronal alterations outside the brain may help to explain a host of the condition’s characteristic traits, including sensory changes, gut problems and motor differences.
On the periphery: Thinking ‘outside the brain’ offers new ideas about autism
Neuronal alterations outside the brain may help to explain a host of the condition’s characteristic traits, including sensory changes, gut problems and motor differences.
Asleep in the Mouse House with Graham Diering
Memories from Diering’s life trace the rising star’s scientific path from raising lizards as a child and later exploring home brewing to heading a lab that investigates memory, sleep disturbances and early development in animals with autism-linked mutations.
Asleep in the Mouse House with Graham Diering
Memories from Diering’s life trace the rising star’s scientific path from raising lizards as a child and later exploring home brewing to heading a lab that investigates memory, sleep disturbances and early development in animals with autism-linked mutations.
One-rosette technique grows well-organized organoids
The method yields complex organoids that more closely mimic embryonic brain development than do those cultured in other ways.
One-rosette technique grows well-organized organoids
The method yields complex organoids that more closely mimic embryonic brain development than do those cultured in other ways.
Mouse models help sniff out olfactory differences in autism
A range of presentations at Neuroscience 2022 tie atypical social behavior to trouble discriminating between odors in the animals.
Mouse models help sniff out olfactory differences in autism
A range of presentations at Neuroscience 2022 tie atypical social behavior to trouble discriminating between odors in the animals.
Double SHANK knockout highlights brain circuit’s social role
Mice missing the autism-linked SHANK2 and SHANK3 genes in their retrosplenial cortex have trouble distinguishing between novel and familiar mice.
Double SHANK knockout highlights brain circuit’s social role
Mice missing the autism-linked SHANK2 and SHANK3 genes in their retrosplenial cortex have trouble distinguishing between novel and familiar mice.
Lost sleep sparks lasting social problems in SHANK3 mice
Sleep disruption early in life has long-lasting consequences for mice missing a copy of the autism-linked gene SHANK3.
Lost sleep sparks lasting social problems in SHANK3 mice
Sleep disruption early in life has long-lasting consequences for mice missing a copy of the autism-linked gene SHANK3.
Explore more from The Transmitter
Are parts of the memory trace found in the ‘astroengram?’
Neurons have long taken top billing in memory, but researchers are making the case for astrocytes.
Are parts of the memory trace found in the ‘astroengram?’
Neurons have long taken top billing in memory, but researchers are making the case for astrocytes.
Crise de financiamento na Argentina desencadeia nova onda de protestos
Dois anos após o colapso do financiamento à pesquisa no país, cientistas estão protestando contra a omissão do governo em restabelecer bolsas que haviam sido cortadas e aumentar os salários, conforme exigido por uma lei de 2025.
Crise de financiamento na Argentina desencadeia nova onda de protestos
Dois anos após o colapso do financiamento à pesquisa no país, cientistas estão protestando contra a omissão do governo em restabelecer bolsas que haviam sido cortadas e aumentar os salários, conforme exigido por uma lei de 2025.
O que as sanguessugas revelam sobre o movimento
Lidia Szczupak recorreu a esses animais para investigar como o sistema nervoso coordena o movimento.
O que as sanguessugas revelam sobre o movimento
Lidia Szczupak recorreu a esses animais para investigar como o sistema nervoso coordena o movimento.