Neurodevelopment
Recent articles
Hasty stem cells highlight potential limitation with cortical organoids
The models recapitulate many key developmental processes, but some radial glial cells in mouse organoids make neurons earlier than they should.
Hasty stem cells highlight potential limitation with cortical organoids
The models recapitulate many key developmental processes, but some radial glial cells in mouse organoids make neurons earlier than they should.
Human brain organoids flourish in emptied mouse cortex
The chimeric mice could help untangle the biology of human brain development or conditions such as autism.
Human brain organoids flourish in emptied mouse cortex
The chimeric mice could help untangle the biology of human brain development or conditions such as autism.
Infant memories: Lost but not gone?
Infantile amnesia is not simply a story about forgetting the past. It is an opportunity to understand how memory itself is built.
Infant memories: Lost but not gone?
Infantile amnesia is not simply a story about forgetting the past. It is an opportunity to understand how memory itself is built.
Autism-linked variants rewire protein networks
The myriad proteins tied to autism cluster in previously unrecognized ways that can be disrupted by specific variants in the proteins.
Autism-linked variants rewire protein networks
The myriad proteins tied to autism cluster in previously unrecognized ways that can be disrupted by specific variants in the proteins.
Nuclear location helps control gene activity during brain development
A study of developing human brain tissue suggests that genes switch on more strongly when they move from the nucleus’s edge toward structures that contain proteins involved in making and processing RNA.
Nuclear location helps control gene activity during brain development
A study of developing human brain tissue suggests that genes switch on more strongly when they move from the nucleus’s edge toward structures that contain proteins involved in making and processing RNA.
Five-year-old human brain organoids aged on schedule
The cultured spheres typically mimic only prenatal development, but the five-year-old ones grown in Paola Arlotta’s lab acquired postnatal features.
Five-year-old human brain organoids aged on schedule
The cultured spheres typically mimic only prenatal development, but the five-year-old ones grown in Paola Arlotta’s lab acquired postnatal features.
Loss of interneuron plasticity may be shared hallmark of neurodevelopmental conditions
Restoring an experience-dependent interneuron plasticity gene in adulthood improves memory and cuts seizures in CNTNAP2 knockout mice, a new study shows.
Loss of interneuron plasticity may be shared hallmark of neurodevelopmental conditions
Restoring an experience-dependent interneuron plasticity gene in adulthood improves memory and cuts seizures in CNTNAP2 knockout mice, a new study shows.
Cortical territories compete in developmental space race
Sensory and association regions are established through a reciprocal process, according to a new model of cortical development.
Cortical territories compete in developmental space race
Sensory and association regions are established through a reciprocal process, according to a new model of cortical development.
Nearly 400 compounds affect behaviors tied to autism-linked genes in zebrafish
Estropipate, paclitaxel and levocarnitine altered behaviors tied to SCN2A and DYRK1A variants specifically, a new open-source platform revealed.
Nearly 400 compounds affect behaviors tied to autism-linked genes in zebrafish
Estropipate, paclitaxel and levocarnitine altered behaviors tied to SCN2A and DYRK1A variants specifically, a new open-source platform revealed.
Largest leucovorin-autism trial retracted
A reanalysis of the data revealed errors and failed to replicate the results.
Largest leucovorin-autism trial retracted
A reanalysis of the data revealed errors and failed to replicate the results.
Explore more from The Transmitter
New projectome captures ‘complex beast’ of serotonin system in mice
The whole-brain map—the first of its kind in a vertebrate—identifies five distinct neuron groups.
New projectome captures ‘complex beast’ of serotonin system in mice
The whole-brain map—the first of its kind in a vertebrate—identifies five distinct neuron groups.
Silent, motion-resistant fMRI expands scans in behaving mice
The method, called SORDINO, captures brain images in animals while they move and interact.
Silent, motion-resistant fMRI expands scans in behaving mice
The method, called SORDINO, captures brain images in animals while they move and interact.
Autism-linked variants converge on two molecular patterns in mouse brains
Gene activity across 17 autism mouse models occurs in either of two opposing transcriptomic states, supporting the idea that diverse genetic changes may converge on a few recurring biological patterns.
Autism-linked variants converge on two molecular patterns in mouse brains
Gene activity across 17 autism mouse models occurs in either of two opposing transcriptomic states, supporting the idea that diverse genetic changes may converge on a few recurring biological patterns.